TPDB

3D PDB MODEL

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TPDB ID TPDB02003

Peptide_Name

DPPIV inhibitor

Activity

Antidiabetic Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AnOxPePred - 1.0 AODB AoXpDb FermFooDB Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (Antidiabetic and Antioxidant) peptide sequence curated from Peptipedia, AnOxPePred - 1.0, AODB, and other sources, with an available 3D structural model.

Sequence

VPYPQ

FASTA

>TPDB02003|Antidiabetic;Antioxidant|length=5
VPYPQ

Formula C29H42N6O8

Absent Amino Acids ARNDCEGHILKMFSTW

Common Amino Acids P

Mass 602.69

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index 0.61

Hydrophobicity -0.760

Aliphatic Index 58.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 247.23

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

5

Formula

C29H42N6O8

Mass

602.69

PI

5.94

Net Charge

-0

Boman Index

0.61

Hydrophobicity

-0.760

Chemical_Mass

602.6775

Monoisotopic_Mass

602.3054

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 41.45 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Zheng L., Xu Q., Lin L., Zeng X., Sun B., Zhao M. M.

Title

In vitro metabolic stability of a casein-derived dipeptidyl peptidase-IV (DPP-IV) inhibitory peptide VPYPQ and its controlled release from casein by enzymatic hydrolysis. J. Agric. Food Chem., 67, 10604-10613, 2019

Year 2019

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C29H42N6O8/c1-16(2)24(31)28(41)35-14-4-6-22(35)26(39)33-20(15-17-7-9-18(36)10-8-17)27(40)34-13-3-5-21(34)25(38)32-19(29(42)43)11-12-23(30)37/h7-10,16,19-22,24,36H,3-6,11-15,31H2,1-2H3,(H2,30,37)(H,32,38)(H,33,39)(H,42,43)/t19-,20-,21-,22-,24-/m0/s1 InChIKey= PNRCORVXKCNAOX-YGQNSOCVSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8278) the MBPDB database

Evidence 2 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB AoXpDb FermFooDB

Source DFBP

Number_of_Residues

5