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Peptide record

TPDB01965

ACE inhibitor Dipeptidyl peptidase IV inhibitor ACE inhibitors Antibacterial Anticancer Antidiabetic Antihypertensive Antioxidant Bitter Umami standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB01965
ACE inhibitor Dipeptidyl peptidase IV inhibitor
ACE inhibitors Antibacterial Anticancer Antidiabetic Antihypertensive Antioxidant Bitter Umami
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Food sensory peptides Functional / health-promoting peptides
FermFooDB Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP pep-lab Tastepeptides-Meta
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
VLPVPQK
Physicochemical Analysis
C37H65N9O9
ARNDCEGHIMFSTWY
PV
779.98
10.10
1
0
3
+1
2.05
0.229
138.57
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
1
L
1
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
7
C37H65N9O9
779.98
10.10
+1
2.05
0.229
779.9643
779.4890
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Magouz O., Ibrahim M. A. A., Mehanna N., Gensberger-Reigl S., Dalabasmaz S., Pischetsrieder M.
Identification of the heptapeptide PR7 and octapeptide SF8 with potent antioxidative and angiotensin converting enzyme inhibitory activity from the fermented dairy by-product “Buttermilk". Food Front., 6, 837–851, 2025
2025
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C37H65N9O9/c1-20(2)19-25(43-34(51)29(40)21(3)4)35(52)45-17-9-13-27(45)33(50)44-30(22(5)6)36(53)46-18-10-12-26(46)32(49)41-23(14-15-28(39)47)31(48)42-24(37(54)55)11-7-8-16-38/h20-27,29-30H,7-19,38,40H2,1-6H3,(H2,39,47)(H,41,49)(H,42,48)(H,43,51)(H,44,50)(H,54,55)/t23-,24-,25-,26-,27-,29-,30-/m0/s1 InChIKey=NKNBSECGZPVWGH-YYLRFZLMSA-N Predicted ligand of Thrombin (EC 3.4.21.5) (MEROPS ID: S01.217) (PDB code: 2BVR) according to the BIOPEP-UWM Virtual database (ID 219) Lipoxygenase inhibitor according to the BIOPEP-UWM database of bioactive peptides (ID 7877) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10243) the MBPDB database Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10242) Peptide stimulating osteoblast differentiation according to the BIOPEP-UWM database of bioactive peptides (ID 10244) the MBPDB database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 10246) the MBPDB database Anti-apoptotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10245) Peptide stimulating fibroblast migration and exhibiting antiaging effect according to the BIOPEP-UWM database of bioactive peptides (ID 10247) the MBPDB database
Evidence 2 Activity

Activity

IC50
Antidiabetic
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Zhang Y., Chen R., Zuo F., Ma H., Zhang Y., Chen S.
Comparison of dipeptidyl peptidase IV-inhibitory activity of peptides from bovine and caprine milk casein by in silico and in vitro analyses. Int. Dairy J., 53, 37-44, 2016
2016
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C37H65N9O9/c1-20(2)19-25(43-34(51)29(40)21(3)4)35(52)45-17-9-13-27(45)33(50)44-30(22(5)6)36(53)46-18-10-12-26(46)32(49)41-23(14-15-28(39)47)31(48)42-24(37(54)55)11-7-8-16-38/h20-27,29-30H,7-19,38,40H2,1-6H3,(H2,39,47)(H,41,49)(H,42,48)(H,43,51)(H,44,50)(H,54,55)/t23-,24-,25-,26-,27-,29-,30-/m0/s1 InChIKey=NKNBSECGZPVWGH-YYLRFZLMSA-N Predicted ligand of Thrombin (EC 3.4.21.5) (MEROPS ID: S01.217) (PDB code: 2BVR) according to the BIOPEP-UWM Virtual database (ID 219) Lipoxygenase inhibitor according to the BIOPEP-UWM database of bioactive peptides (ID 7877) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides the MBPDB database (ID 10243) Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10242) Peptide stimulating osteoblast differentiation according to the BIOPEP-UWM database of bioactive peptides the MBPDB database (ID 10244) Anti-apoptotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10245) Peptide stimulating fibroblast migration and exhibiting antiaging effect according to the BIOPEP-UWM database of bioactive peptides (ID 10247)
Evidence 3 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Magouz O., Ibrahim M. A. A., Mehanna N., Gensberger-Reigl S., Dalabasmaz S., Pischetsrieder M.
Identification of the heptapeptide PR7 and octapeptide SF8 with potent antioxidative and angiotensin converting enzyme inhibitory activity from the fermented dairy by-product “Buttermilk". Food Front., 6, 837–851, 2025
2025
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C37H65N9O9/c1-20(2)19-25(43-34(51)29(40)21(3)4)35(52)45-17-9-13-27(45)33(50)44-30(22(5)6)36(53)46-18-10-12-26(46)32(49)41-23(14-15-28(39)47)31(48)42-24(37(54)55)11-7-8-16-38/h20-27,29-30H,7-19,38,40H2,1-6H3,(H2,39,47)(H,41,49)(H,42,48)(H,43,51)(H,44,50)(H,54,55)/t23-,24-,25-,26-,27-,29-,30-/m0/s1 InChIKey=NKNBSECGZPVWGH-YYLRFZLMSA-N Predicted ligand of Thrombin (EC 3.4.21.5) (MEROPS ID: S01.217) (PDB code: 2BVR) according to the BIOPEP-UWM Virtual database (ID 219) Lipoxygenase inhibitor according to the BIOPEP-UWM database of bioactive peptides (ID 7877) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10243) the MBPDB database Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10242) Peptide stimulating osteoblast differentiation according to the BIOPEP-UWM database of bioactive peptides (ID 10244) the MBPDB database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 10246) the MBPDB database Anti-apoptotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10245) Peptide stimulating fibroblast migration and exhibiting antiaging effect according to the BIOPEP-UWM database of bioactive peptides (ID 10247) the MBPDB database
Evidence 4 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB FermFooDB
DFBP
Additional Detail Fields 1 fields
7