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Peptide record

TPDB01960

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB01960
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
pep-lab Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
VLPIPQ
Physicochemical Analysis
C32H55N7O8
ARNDCEGHKMFSTWY
P
665.83
6.02
0
0
3
-0
0.68
0.967
178.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
6
C32H55N7O8
665.83
6.02
-0
0.68
0.967
665.8190
665.4099
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
5300.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C32H55N7O8/c1-7-19(6)26(31(45)39-15-9-10-22(39)27(41)35-20(32(46)47)12-13-24(33)40)37-28(42)23-11-8-14-38(23)30(44)21(16-17(2)3)36-29(43)25(34)18(4)5/h17-23,25-26H,7-16,34H2,1-6H3,(H2,33,40)(H,35,41)(H,36,43)(H,37,42)(H,46,47)/t19-,20-,21-,22-,23-,25-,26-/m0/s1 InChIKey: JHWMCQQHLVOYEE-DRKCKIEBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
5300.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C32H55N7O8/c1-7-19(6)26(31(45)39-15-9-10-22(39)27(41)35-20(32(46)47)12-13-24(33)40)37-28(42)23-11-8-14-38(23)30(44)21(16-17(2)3)36-29(43)25(34)18(4)5/h17-23,25-26H,7-16,34H2,1-6H3,(H2,33,40)(H,35,41)(H,36,43)(H,37,42)(H,46,47)/t19-,20-,21-,22-,23-,25-,26-/m0/s1 InChIKey: JHWMCQQHLVOYEE-DRKCKIEBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
6