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Peptide record

TPDB01941

Antibacterial Antifungal Antioxidant Hemolysis Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB01941
Antibacterial Antifungal Antioxidant Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb APD_complete APD_hemolytic Hemolytic2
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antifungal, Antioxidant, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VKLFPVKLFP
Physicochemical Analysis
C62H98N12O11
ARNDCEQGHIMSTWY
LKFPV
1187.53
10.60
2
0
6
+2
-0.36
1.060
136.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
2
K
0
M
2
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 2 M: 0 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
10
C62H98N12O11
1187.53
10.60
+2
-0.36
1.060
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.9 µg/mL

Target

E. faecium

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
bactericidal: active against 15 strains E. faecium (MIC 3.9 ug/ml), 15 S. aureus (MIC 3.9-7.8 ug/ml), E. cloacae (MIC 1.95-62.5 ug/ml), 15 P. aeruginosa (MI
Evidence 2 Activity

Activity

MIC
Antibacterial
3.9-7.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

bactericidal: active against 15 strains E. faecium (MIC 3.9 ug/ml), 15 S. aureus (MIC 3.9-7.8 ug/ml), E. cloacae (MIC 1.95-62.5 ug/ml), 15 P. aeruginosa (MIC 31.2-62.5 ug/ml), 15 K. pneumoni
Evidence 3 Activity

Activity

MIC
Antibacterial
1.95-62.5 µg/mL

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP

Other

: active against 15 strains E. faecium (MIC 3.9 ug/ml), 15 S. aureus (MIC 3.9-7.8 ug/ml), E. cloacae (MIC 1.95-62.5 ug/ml), 15 P. aeruginosa (MIC 31.2-62.5 ug/ml), 15 K. pneumoniae (MIC 7.8-62.5 ug/ml), and 15 A.
Evidence 4 Activity

Activity

MIC
Antibacterial
31.2-62.5 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

m (MIC 3.9 ug/ml), 15 S. aureus (MIC 3.9-7.8 ug/ml), E. cloacae (MIC 1.95-62.5 ug/ml), 15 P. aeruginosa (MIC 31.2-62.5 ug/ml), 15 K. pneumoniae (MIC 7.8-62.5 ug/ml), and 15 A. baumannii (MIC 31.2-62.5 ug/ml) ( Swier
Evidence 5 Activity

Activity

MIC
Antibacterial
7.8-62.5 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

-7.8 ug/ml), E. cloacae (MIC 1.95-62.5 ug/ml), 15 P. aeruginosa (MIC 31.2-62.5 ug/ml), 15 K. pneumoniae (MIC 7.8-62.5 ug/ml), and 15 A. baumannii (MIC 31.2-62.5 ug/ml) ( Swierstra et al., 2016 ).
Evidence 6 Activity

Activity

MIC
Antibacterial
31.2-62.5 µg/mL

Target

A. baumannii

Source & Reference

dbAMP DRAMP

Other

l), 15 P. aeruginosa (MIC 31.2-62.5 ug/ml), 15 K. pneumoniae (MIC 7.8-62.5 ug/ml), and 15 A. baumannii (MIC 31.2-62.5 ug/ml) ( Swierstra et al., 2016 ).
Evidence 7 Activity

Activity

MIC
Antifungal
3.9 µg/mL

Target

E. faecium

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
bactericidal: active against 15 strains E. faecium (MIC 3.9 ug/ml), 15 S. aureus (MIC 3.9-7.8 ug/ml), E. cloacae (MIC 1.95-62.5 ug/ml), 15 P. aeruginosa (MI
Evidence 8 Activity

Activity

MIC
Antifungal
3.9-7.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb

Other

bactericidal: active against 15 strains E. faecium (MIC 3.9 ug/ml), 15 S. aureus (MIC 3.9-7.8 ug/ml), E. cloacae (MIC 1.95-62.5 ug/ml), 15 P. aeruginosa (MIC 31.2-62.5 ug/ml), 15 K. pneumoni
Evidence 9 Activity

Activity

MIC
Antifungal
1.95-62.5 µg/mL

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP CAFPdb

Other

: active against 15 strains E. faecium (MIC 3.9 ug/ml), 15 S. aureus (MIC 3.9-7.8 ug/ml), E. cloacae (MIC 1.95-62.5 ug/ml), 15 P. aeruginosa (MIC 31.2-62.5 ug/ml), 15 K. pneumoniae (MIC 7.8-62.5 ug/ml), and 15 A.
Evidence 10 Activity

Activity

MIC
Antifungal
31.2-62.5 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb

Other

m (MIC 3.9 ug/ml), 15 S. aureus (MIC 3.9-7.8 ug/ml), E. cloacae (MIC 1.95-62.5 ug/ml), 15 P. aeruginosa (MIC 31.2-62.5 ug/ml), 15 K. pneumoniae (MIC 7.8-62.5 ug/ml), and 15 A. baumannii (MIC 31.2-62.5 ug/ml) ( Swier
Evidence 11 Activity

Activity

MIC
Antifungal
7.8-62.5 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb

Other

-7.8 ug/ml), E. cloacae (MIC 1.95-62.5 ug/ml), 15 P. aeruginosa (MIC 31.2-62.5 ug/ml), 15 K. pneumoniae (MIC 7.8-62.5 ug/ml), and 15 A. baumannii (MIC 31.2-62.5 ug/ml) ( Swierstra et al., 2016 ).
Evidence 12 Activity

Activity

MIC
Antifungal
31.2-62.5 µg/mL

Target

A. baumannii

Source & Reference

dbAMP DRAMP CAFPdb

Other

l), 15 P. aeruginosa (MIC 31.2-62.5 ug/ml), 15 K. pneumoniae (MIC 7.8-62.5 ug/ml), and 15 A. baumannii (MIC 31.2-62.5 ug/ml) ( Swierstra et al., 2016 ).
Evidence 13 Activity

Activity

Hemolysis
Hemolysis
25 µM
It exhibits hemolytic activity at 25 µM and 45 µM against human red cells and sheep red cells.

Source & Reference

APD_complete APD_hemolytic
DRAMP4
Int J Pept Protein Res. 1996 Jun 47(6):460-6.##Biochim Biophys Acta. 2014 May 1838(5):1420-9.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.
Evidence 14 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: It exhibits hemolytic activity at 25 µM and 45 µM against human red cells and sheep red cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Pept Protein Res. 1996 Jun 47(6):460-6.##Biochim Biophys Acta. 2014 May 1838(5):1420-9.
Evidence 15 Hemolysis

Activity

25 µM
Hemolysis
It exhibits hemolytic activity at 25 µM and 45 µM against human red cells and sheep red cells.
Hemolysis

Source & Reference

APD_complete APD_hemolytic
Int J Pept Protein Res. 1996 Jun 47(6):460-6.##Biochim Biophys Acta. 2014 May 1838(5):1420-9.
DRAMP4
APD_complete APD_hemolytic