TPDB

3D PDB MODEL

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TPDB ID TPDB01926

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

VIEPR

FASTA

>TPDB01926|ACE inhibitors;Antioxidant|length=5
VIEPR

Formula C27H48N8O8

Absent Amino Acids ANDCQGHLKMFSTWY

Common Amino Acids REIPV

Mass 612.73

PI 6.97

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -0

Boman Index 3.04

Hydrophobicity -0.180

Aliphatic Index 136.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

1

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

5

Formula

C27H48N8O8

Mass

612.73

PI

6.97

Net Charge

-0

Boman Index

3.04

Hydrophobicity

-0.180

Chemical_Mass

612.7169

Monoisotopic_Mass

612.3584

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 632.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zheng Y., Li Y., Zhang Y., Ruan X., Zhang R.

Title

Purification, characterization, synthesis, in vitro ACE inhibition andin vivo antihypertensive activity of bioactive peptides derived from oilpalm kernel glutelin-2 hydrolysates. J. Funct. Foods, 28, 48-58, 2017

Year 2017

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C27H48N8O8/c1-5-15(4)21(34-23(39)20(28)14(2)3)24(40)32-16(10-11-19(36)37)25(41)35-13-7-9-18(35)22(38)33-17(26(42)43)8-6-12-31-27(29)30/h14-18,20-21H,5-13,28H2,1-4H3,(H,32,40)(H,33,38)(H,34,39)(H,36,37)(H,42,43)(H4,29,30,31)/t15-,16-,17-,18-,20-,21-/m0/s1 InChIKey: ICMMMJUYZHKULL-ZKHIMWLXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9717) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9718)

Number_of_Residues

5