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Peptide record

TPDB01916

ACE inhibitor (fragment of bovine a-La) ACE inhibitors Antihypertensive Antioxidant standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB01916
ACE inhibitor (fragment of bovine a-La)
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
pep-lab Peptipedia AHTPDB AHTpin AoXpDb
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
VGINYWLAHK
Physicochemical Analysis
C58H85N15O13
RDCEQMFPST
ANGHILKWYV
1200.41
9.74
2
0
6
+1
-1.38
0.110
117.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
6990
582.30
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
10
C58H85N15O13
1200.41
9.74
+1
-1.38
0.110
1200.3848
1199.6432
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
327.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Pihlanto-Leppälä A., Koskinen P., Piilola K., Tupasela T., Korhonen H.
Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64, 2000
2000
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C58H85N15O13/c1-8-32(6)49(73-47(76)28-64-56(83)48(61)31(4)5)57(84)72-45(25-46(60)75)55(82)70-42(22-34-16-18-37(74)19-17-34)52(79)71-43(23-35-26-63-39-14-10-9-13-38(35)39)53(80)69-41(21-30(2)3)51(78)66-33(7)50(77)68-44(24-36-27-62-29-65-36)54(81)67-40(58(85)86)15-11-12-20-59/h9-10,13-14,16-19,26-27,29-33,40-45,48-49,63,74H,8,11-12,15,20-25,28,59,61H2,1-7H3,(H2,60,75)(H,62,65)(H,64,83)(H,66,78)(H,67,81)(H,68,77)(H,69,80)(H,70,82)(H,71,79)(H,72,84)(H,73,76)(H,85,86)/t32-,33-,40-,41-,42-,43-,44-,45-,48-,49-/m0/s1 InChIKey=ZYIXBRULWUVEPE-AWOWTVRJSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
327.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Pihlanto-Leppälä A., Koskinen P., Piilola K., Tupasela T., Korhonen H.
Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64, 2000
2000
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C58H85N15O13/c1-8-32(6)49(73-47(76)28-64-56(83)48(61)31(4)5)57(84)72-45(25-46(60)75)55(82)70-42(22-34-16-18-37(74)19-17-34)52(79)71-43(23-35-26-63-39-14-10-9-13-38(35)39)53(80)69-41(21-30(2)3)51(78)66-33(7)50(77)68-44(24-36-27-62-29-65-36)54(81)67-40(58(85)86)15-11-12-20-59/h9-10,13-14,16-19,26-27,29-33,40-45,48-49,63,74H,8,11-12,15,20-25,28,59,61H2,1-7H3,(H2,60,75)(H,62,65)(H,64,83)(H,66,78)(H,67,81)(H,68,77)(H,69,80)(H,70,82)(H,71,79)(H,72,84)(H,73,76)(H,85,86)/t32-,33-,40-,41-,42-,43-,44-,45-,48-,49-/m0/s1 InChIKey=ZYIXBRULWUVEPE-AWOWTVRJSA-N
Additional Detail Fields 1 fields
10