TPDB

3D PDB MODEL

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TPDB ID TPDB01899

Peptide_Name

ACE inhibitor

Activity

Antihypertensive Antioxidant iDPPIV

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

AHTPDB Peptipedia AODB iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (Antihypertensive, Antioxidant, and iDPPIV) peptide sequence curated from AHTPDB, Peptipedia, AODB, and other sources, with an available 3D structural model.

Sequence

VEP

FASTA

>TPDB01899|Antihypertensive;Antioxidant;iDPPIV|length=3
VEP

Formula C15H25N3O6

Absent Amino Acids ARNDCQGHILKMFSTWY

Common Amino Acids EPV

Mass 343.38

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -1

Boman Index 2.54

Hydrophobicity -0.300

Aliphatic Index 96.67

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

3

Formula

C15H25N3O6

Mass

343.38

PI

3.29

Net Charge

-1

Boman Index

2.54

Hydrophobicity

-0.300

Chemical_Mass

343.3745

Monoisotopic_Mass

343.1737

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 40.88 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Gu J., Yue S., Yang X., Lu Z., Wang Z., Wei X., Zhou L., Zhao Z., Shi Z., Zhao Z.

Title

Unlocking novel angiotensin-converting enzyme inhibitory peptides from Nili Ravi buffalo milk β-casein: A synergistic strategy combining targeted hydrolysis, 3D-QSAR modeling, and mechanistic insights. Food Biosci., 71, 107346, 2025

Year 2025

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C15H25N3O6/c1-8(2)12(16)13(21)17-9(5-6-11(19)20)14(22)18-7-3-4-10(18)15(23)24/h8-10,12H,3-7,16H2,1-2H3,(H,17,21)(H,19,20)(H,23,24)/t9-,10-,12-/m0/s1 InChIKey=WDIGUPHXPBMODF-NHCYSSNCSA-N

Number_of_Residues

3