Back to search

Peptide record

TPDB01889

ACE inhibitor ACE inhibitors Anticancer Antihypertensive Antioxidant standard
11 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB01889
ACE inhibitor
ACE inhibitors Anticancer Antihypertensive Antioxidant
Cardiometabolic peptides Cancer-related peptides Functional / health-promoting peptides
Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 11-aa standard natural multi-activity (ACE inhibitors, Anticancer, Antihypertensive, and other sources) peptide sequence curated from Peptipedia, ACP740 _ACP240, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
VECYGPNRPQF
Physicochemical Analysis
C58H84N16O17S1
ADHILKMSTW
P
1309.46
6.28
1
1
3
-0
2.50
-0.945
26.36
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
113.79
4
Residue Composition
number
0
A
1
R
1
N
0
D
1
C
1
E
1
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 1 E: 1 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
11
C58H84N16O17S1
1309.46
6.28
-0
2.50
-0.945
1309.4473
1308.5902
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
29.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Sheih I.-C., Fang T. J., Wu T.-K.
Isolation and characterisation of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide from the algae protein waste. Food Chem., 115, 279-284, 2009
2009
Journal

Other

11
BIOPEP-UWM database bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C58H84N16O17S/c1-30(2)47(61)55(88)67-35(19-21-46(79)80)50(83)72-40(29-92)52(85)69-37(25-32-14-16-33(75)17-15-32)48(81)65-28-45(78)73-23-7-12-41(73)53(86)70-38(27-44(60)77)51(84)68-36(11-6-22-64-58(62)63)56(89)74-24-8-13-42(74)54(87)66-34(18-20-43(59)76)49(82)71-39(57(90)91)26-31-9-4-3-5-10-31/h3-5,9-10,14-17,30,34-42,47,75,92H,6-8,11-13,18-29,61H2,1-2H3,(H2,59,76)(H2,60,77)(H,65,81)(H,66,87)(H,67,88)(H,68,84)(H,69,85)(H,70,86)(H,71,82)(H,72,83)(H,79,80)(H,90,91)(H4,62,63,64)/t34-,35-,36-,37-,38-,39-,40-,41-,42-,47-/m0/s1 InChIKey: MKKYPTUWZLUJKL-VGGCNYALSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8138) Anticancer peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8137)
Evidence 2 Activity

Activity

IC50
Antihypertensive
29.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Sheih I.-C., Fang T. J., Wu T.-K.
Isolation and characterisation of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide from the algae protein waste. Food Chem., 115, 279-284, 2009
2009
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
11
BIOPEP-UWM database bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C58H84N16O17S/c1-30(2)47(61)55(88)67-35(19-21-46(79)80)50(83)72-40(29-92)52(85)69-37(25-32-14-16-33(75)17-15-32)48(81)65-28-45(78)73-23-7-12-41(73)53(86)70-38(27-44(60)77)51(84)68-36(11-6-22-64-58(62)63)56(89)74-24-8-13-42(74)54(87)66-34(18-20-43(59)76)49(82)71-39(57(90)91)26-31-9-4-3-5-10-31/h3-5,9-10,14-17,30,34-42,47,75,92H,6-8,11-13,18-29,61H2,1-2H3,(H2,59,76)(H2,60,77)(H,65,81)(H,66,87)(H,67,88)(H,68,84)(H,69,85)(H,70,86)(H,71,82)(H,72,83)(H,79,80)(H,90,91)(H4,62,63,64)/t34-,35-,36-,37-,38-,39-,40-,41-,42-,47-/m0/s1 InChIKey: MKKYPTUWZLUJKL-VGGCNYALSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8138) Anticancer peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8137)
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
11