TPDB

3D PDB MODEL

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TPDB ID TPDB01865

Peptide_Name

ACE inhibitor

Activity

Antihypertensive Antioxidant iDPPIV

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

AHTPDB AHTpin Peptipedia AoXpDb iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (Antihypertensive, Antioxidant, and iDPPIV) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.

Sequence

VAPFPEV

FASTA

>TPDB01865|Antihypertensive;Antioxidant;iDPPIV|length=7
VAPFPEV

Formula C37H55N7O10

Absent Amino Acids RNDCQGHILKMSTWY

Common Amino Acids PV

Mass 757.88

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -1

Boman Index 1.76

Hydrophobicity 0.900

Aliphatic Index 97.14

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

2

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

7

Formula

C37H55N7O10

Mass

757.88

PI

3.29

Net Charge

-1

Boman Index

1.76

Hydrophobicity

0.900

Chemical_Mass

757.8713

Monoisotopic_Mass

757.3997

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Magouz O., Ibrahim M. A. A., Mehanna N., Gensberger-Reigl S., Dalabasmaz S., Pischetsrieder M.

Title

Identification of the heptapeptide PR7 and octapeptide SF8 with potent antioxidative and angiotensin converting enzyme inhibitory activity from the fermented dairy by-product “Buttermilk". Food Front., 6, 837–851, 2025

Year 2025

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C37H55N7O10/c1-20(2)29(38)34(50)39-22(5)35(51)43-17-9-13-26(43)33(49)41-25(19-23-11-7-6-8-12-23)36(52)44-18-10-14-27(44)32(48)40-24(15-16-28(45)46)31(47)42-30(21(3)4)37(53)54/h6-8,11-12,20-22,24-27,29-30H,9-10,13-19,38H2,1-5H3,(H,39,50)(H,40,48)(H,41,49)(H,42,47)(H,45,46)(H,53,54)/t22-,24-,25-,26-,27-,29-,30-/m0/s1 InChIKey=NKBNJBMJISHPIG-KNWHVVHCSA-N

Number_of_Residues

7