TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB01863

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

VAPEEHPV

FASTA

>TPDB01863|ACE inhibitors;Antioxidant|length=8
VAPEEHPV

Formula C39H60N10O13

Absent Amino Acids RNDCQGILKMFSTWY

Common Amino Acids EPV

Mass 876.96

PI 4.25

Basic Residues 1

Acidic Residues 2

Hydrophobic Residues 3

Net Charge -2

Boman Index 5.87

Hydrophobicity -0.400

Aliphatic Index 85.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

2

E

0

Q

0

G

1

H

0

I

0

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

8

Formula

C39H60N10O13

Mass

876.96

PI

4.25

Net Charge

-2

Boman Index

5.87

Hydrophobicity

-0.400

Chemical_Mass

876.9505

Monoisotopic_Mass

876.4327

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 21.51 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zielińska E., Karaś M., Baraniak B., Jakubczyk A.

Title

Evaluation of ACE, alpha‑glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects. Eur. Food Res. Technol., 246, 1361-1369, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC2=C[N]([H])C=N2)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](C(C)C)C(=O)O InChI=1S/C36H62N10O10/c1-6-19(3)27(37)31(51)44-28(20(4)7-2)32(52)41-21(5)33(53)46-18-10-13-25(46)34(54)45-17-9-12-24(45)30(50)42-22(14-15-26(47)48)29(49)43-23(35(55)56)11-8-16-40-36(38)39/h19-25,27-28H,6-18,37H2,1-5H3,(H,41,52)(H,42,50)(H,43,49)(H,44,51)(H,47,48)(H,55,56)(H4,38,39,40)/t19-,20-,21-,22-,23-,24-,25-,27-,28-/m0/s1 InChIKey=ZHQCNOJJTASHDW-ADWUDYDCSA-N Inhibitor of pancreatic lipase according to the BIOPEP-UWM database of bioactive peptides (ID 9822)

Number_of_Residues

8