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Peptide record

TPDB01859

ACE inhibitor (beta-Lg 15-20) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Antihypertensive Antioxidant iDPPIV standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB01859
ACE inhibitor (beta-Lg 15-20) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antibacterial Antihypertensive Antioxidant iDPPIV
Anti-infective peptides Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP iDPPIV
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antihypertensive, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
VAGTWY
Physicochemical Analysis
C34H45N7O9
RNDCEQHILKMFPS
AGTWYV
695.77
5.94
0
0
4
-0
-2.74
0.450
65.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
6990
1004.64
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 1
Chemical Descriptors
6
C34H45N7O9
695.77
5.94
-0
-2.74
0.450
695.7608
695.3268
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1682.00 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Pihlanto-Leppala A., Rokka T., Korhonen H.
Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal 8, 325-331(1998)
1998
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@@]([H])(N)C(C)C)C(=O)NCC(=O)N[C@]([H])(C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O)[C@@]([H])(C)O InChI=1S/C34H45N7O9/c1-17(2)28(35)32(47)38-18(3)30(45)37-16-27(44)41-29(19(4)42)33(48)39-25(14-21-15-36-24-8-6-5-7-23(21)24)31(46)40-26(34(49)50)13-20-9-11-22(43)12-10-20/h5-12,15,17-19,25-26,28-29,36,42-43H,13-14,16,35H2,1-4H3,(H,37,45)(H,38,47)(H,39,48)(H,40,46)(H,41,44)(H,49,50)/t18-,19+,25-,26-,28-,29-/m0/s1 InChIKey=UAXLUTAGJSXJNR-WVTHTGLTSA-N Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 4014) the EROP-Moscow database the MBPDB database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8523) the MBPDB database Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8498) the MBPDB database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9435) the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
1682.00 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Pihlanto-Leppala A., Rokka T., Korhonen H.
Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal 8, 325-331(1998)
1998
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@@]([H])(N)C(C)C)C(=O)NCC(=O)N[C@]([H])(C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O)[C@@]([H])(C)O InChI=1S/C34H45N7O9/c1-17(2)28(35)32(47)38-18(3)30(45)37-16-27(44)41-29(19(4)42)33(48)39-25(14-21-15-36-24-8-6-5-7-23(21)24)31(46)40-26(34(49)50)13-20-9-11-22(43)12-10-20/h5-12,15,17-19,25-26,28-29,36,42-43H,13-14,16,35H2,1-4H3,(H,37,45)(H,38,47)(H,39,48)(H,40,46)(H,41,44)(H,49,50)/t18-,19+,25-,26-,28-,29-/m0/s1 InChIKey=UAXLUTAGJSXJNR-WVTHTGLTSA-N Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 4014) the EROP-Moscow database the MBPDB database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8523) the MBPDB database Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8498) the MBPDB database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9435) the MBPDB database
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Evidence 4 Activity

Activity

IC50
iDPPIV
174.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lacroix I. M. E., Li-Chan E. C. Y.
Evaluation of the potential of dietary proteins as precursors of dipeptidyl peptidase (DPP)-IV inhibitors by an in silico approach. J. Funct. Foods, 4, 403-422, 2012
2012
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@@]([H])(N)C(C)C)C(=O)NCC(=O)N[C@]([H])(C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O)[C@@]([H])(C)O InChI=1S/C34H45N7O9/c1-17(2)28(35)32(47)38-18(3)30(45)37-16-27(44)41-29(19(4)42)33(48)39-25(14-21-15-36-24-8-6-5-7-23(21)24)31(46)40-26(34(49)50)13-20-9-11-22(43)12-10-20/h5-12,15,17-19,25-26,28-29,36,42-43H,13-14,16,35H2,1-4H3,(H,37,45)(H,38,47)(H,39,48)(H,40,46)(H,41,44)(H,49,50)/t18-,19+,25-,26-,28-,29-/m0/s1 InChIKey=UAXLUTAGJSXJNR-WVTHTGLTSA-N Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 3509) Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 4014), the MBPDB database Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8498) the MBPDB database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9435) the MBPDB database
Additional Detail Fields 1 fields
6