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Peptide record

TPDB01712

Antibacterial Anticancer Antifungal Antioxidant Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB01712
Antibacterial Anticancer Antifungal Antioxidant Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 Peptipedia AFP-GFuse CAFPdb dbAMP AODB
standard
No
A 40-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
SLFSLIKAGAKFLGKNMLKQGPQYPACKVSKDSENVNWKS
Physicochemical Analysis
C199H319N53O56S2
RHT
K
4414.16
10.27
7
2
15
+5
5.74
-0.473
70.75
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
6990
158.35
12
Residue Composition
number
3
A
0
R
3
N
1
D
1
C
1
E
2
Q
3
G
0
H
1
I
4
L
7
K
1
M
2
F
2
P
5
S
0
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 3 D: 1 C: 1 E: 1 Q: 2 G: 3 H: 0 I: 1 L: 4 K: 7 M: 1 F: 2 P: 2 S: 5 T: 0 W: 1 Y: 1 V: 2
Chemical Descriptors
40
C199H319N53O56S2
4414.16
10.27
+5
5.74
-0.473
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
30 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli, S. enterica, and P. aeruginosa and the fungus C. albicans (MIC 30 uM) but inactive against S.aureus. Brevinin-2SSb also possessed significant activities and, a
Evidence 2 Activity

Activity

MIC
Antifungal
30 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli, S. enterica, and P. aeruginosa and the fungus C. albicans (MIC 30 uM) but inactive against S.aureus. Brevinin-2SSb also possessed significant activities and, a
Evidence 3 Activity

Activity

88.5% Killing
Toxicity
32 µg/mL
Cytotoxic
88.5% Killing | 32 | µg/mL | target cell: Monkey COS-7 cells

Target

Monkey COS-7 cells

Source & Reference

NA
DBAASP
Antimicrobial Property and Mode of Action of the Skin Peptides of the Sado Wrinkled Frog, Glandirana susurra, against Animal and Plant Pathogens. | Antibiotics (Basel) | 2020
Evidence 4 Activity

Activity

99.2% Killing
Toxicity
32 µg/mL
Cytotoxic
99.2% Killing | 32 | µg/mL | target cell: Calf pulmonary artery endothelium (CPAE)

Target

Calf pulmonary artery endothelium (CPAE)

Source & Reference

NA
DBAASP
Antimicrobial Property and Mode of Action of the Skin Peptides of the Sado Wrinkled Frog, Glandirana susurra, against Animal and Plant Pathogens. | Antibiotics (Basel) | 2020
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: COS-7: 88.5% Killing=32µg/ml CPAE: 99.2% Killing=32µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2020 Jul 29 9(8):457.