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Peptide record

TPDB01707

Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Toxicity standard

26 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB01707

Activity

Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb AnOxPePred - 1.0 AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

SIITMTKEAKLPQLWKQIACRLYNTC

FASTA

>TPDB01707|Antibacterial;Anticancer;Antifungal;Antioxidant;Antiparasitic;Toxicity|length=26
SIITMTKEAKLPQLWKQIACRLYNTC

Formula C136H226N36O37S3

Absent Amino Acids DGHFV

Common Amino Acids ILKT

Mass 3053.69

PI 9.63

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 11

Net Charge +3

Boman Index 1.93

Hydrophobicity -0.058

Aliphatic Index 97.69

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 7115

Absorbance 280nm 233.00

Polar Residues 10

number

Amino Acid Distribution

A: 2 R: 1 N: 1 D: 0 C: 2 E: 1 Q: 2 G: 0 H: 0 I: 3 L: 3 K: 3 M: 1 F: 0 P: 1 S: 1 T: 3 W: 1 Y: 1 V: 0

Length

Formula

C136H226N36O37S3

Mass

3053.69

9.63

Net Charge

Boman Index

1.93

Hydrophobicity

-0.058

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 60 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 60 ug/ml), S. aureus ATCC2592 (MIC 15 ug/ml), B.subtilis ATCC 6633 (MIC 120 ug/ml), H. pylori NCTC1

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 60 ug/ml), S. aureus ATCC2592 (MIC 15 ug/ml), B.subtilis ATCC 6633 (MIC 120 ug/ml), H. pylori NCTC11637 (MIC 30 ug/ml), and C. albican

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 120 µg/mL

Target

Target Organism B.subtilis ATCC 6633

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 60 ug/ml), S. aureus ATCC2592 (MIC 15 ug/ml), B.subtilis ATCC 6633 (MIC 120 ug/ml), H. pylori NCTC11637 (MIC 30 ug/ml), and C. albicans ATCC2002 (MIC 30 ug/ml). Members of

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism H. pylori NCTC11637

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 60 ug/ml), S. aureus ATCC2592 (MIC 15 ug/ml), B.subtilis ATCC 6633 (MIC 120 ug/ml), H. pylori NCTC11637 (MIC 30 ug/ml), and C. albicans ATCC2002 (MIC 30 ug/ml). Members of the new peptide family named pleurai

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

15 ug/ml), B.subtilis ATCC 6633 (MIC 120 ug/ml), H. pylori NCTC11637 (MIC 30 ug/ml), and C. albicans ATCC2002 (MIC 30 ug/ml). Members of the new peptide family named pleurain-As are composed of 26 amino acids with

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 60 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 60 ug/ml), S. aureus ATCC2592 (MIC 15 ug/ml), B.subtilis ATCC 6633 (MIC 120 ug/ml), H. pylori NCTC1

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 60 ug/ml), S. aureus ATCC2592 (MIC 15 ug/ml), B.subtilis ATCC 6633 (MIC 120 ug/ml), H. pylori NCTC11637 (MIC 30 ug/ml), and C. albican

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 120 µg/mL

Target

Target Organism B.subtilis ATCC 6633

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism H. pylori NCTC11637

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 60 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli ATCC25922 (MIC 60 ug/ml), S. aureus ATCC2592 (MIC 15 ug/ml), B.subtilis ATCC 6633 (MIC 120 ug/ml), H. pylori NCTC1

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 60 ug/ml), S. aureus ATCC2592 (MIC 15 ug/ml), B.subtilis ATCC 6633 (MIC 120 ug/ml), H. pylori NCTC11637 (MIC 30 ug/ml), and C. albican

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 120 µg/mL

Target

Target Organism B.subtilis ATCC 6633

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism H. pylori NCTC11637

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 16 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 µg/ml

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2007 Oct 28(10):2069-2074.