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Peptide record

TPDB01654

ACE inhibitor from bovine alphas1-CN (90-94) Hypotensive peptide ACE inhibitors Antihypertensive Antioxidant standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB01654
ACE inhibitor from bovine alphas1-CN (90-94) Hypotensive peptide
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
RYLGY
Physicochemical Analysis
C32H46N8O8
ANDCEQHIKMFPSTWV
Y
670.77
9.63
1
0
3
+1
-1.62
-0.740
78.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
2980
444.27
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
5
C32H46N8O8
670.77
9.63
+1
-1.62
-0.740
670.7546
670.3428
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.71 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Stuknyte M., Cattaneo S., Masotti F., De Noni, I.
Occurrence and fate of ACE-inhibitor peptides in cheeses and in their digestates following in vitro static gastrointestinal digestion. Food Chemistry, 168, 27-33, 2015
2015
Journal

Other

5
BIOPEP-UWM database of bioactive peptides N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O InChI=1S/C32H46N8O8/c1-18(2)14-24(29(45)37-17-27(43)38-26(31(47)48)16-20-7-11-22(42)12-8-20)40-30(46)25(15-19-5-9-21(41)10-6-19)39-28(44)23(33)4-3-13-36-32(34)35/h5-12,18,23-26,41-42H,3-4,13-17,33H2,1-2H3,(H,37,45)(H,38,43)(H,39,44)(H,40,46)(H,47,48)(H4,34,35,36)/t23-,24-,25-,26-/m0/s1 InChIKey=CBRRRBFAHUNAGF-CQJMVLFOSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10054) the MBPDB database Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.71 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Stuknyte M., Cattaneo S., Masotti F., De Noni, I.
Occurrence and fate of ACE-inhibitor peptides in cheeses and in their digestates following in vitro static gastrointestinal digestion. Food Chemistry, 168, 27-33, 2015
2015
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O InChI=1S/C32H46N8O8/c1-18(2)14-24(29(45)37-17-27(43)38-26(31(47)48)16-20-7-11-22(42)12-8-20)40-30(46)25(15-19-5-9-21(41)10-6-19)39-28(44)23(33)4-3-13-36-32(34)35/h5-12,18,23-26,41-42H,3-4,13-17,33H2,1-2H3,(H,37,45)(H,38,43)(H,39,44)(H,40,46)(H,47,48)(H4,34,35,36)/t23-,24-,25-,26-/m0/s1 InChIKey=CBRRRBFAHUNAGF-CQJMVLFOSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10054) the MBPDB database Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides the MBPDB database
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Lowering blood pressure in rats
hypotensive
hyp

Source & Reference

AHTPDB
Sánchez-Rivera L., Ferreira Santos P., Sevilla M. A., Montero M. J., Recio I., Miralles B.
Implication of opioid receptors in the antihypertensive effect of a bovine casein hydrolysate and αs1-casein-derived peptides. J. Agric. Food Chem., 68, 1877–1883, 2020
2020
Journal

Other

5
BIOPEP-UWM database of bioactive peptides N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O InChI=1S/C32H46N8O8/c1-18(2)14-24(29(45)37-17-27(43)38-26(31(47)48)16-20-7-11-22(42)12-8-20)40-30(46)25(15-19-5-9-21(41)10-6-19)39-28(44)23(33)4-3-13-36-32(34)35/h5-12,18,23-26,41-42H,3-4,13-17,33H2,1-2H3,(H,37,45)(H,38,43)(H,39,44)(H,40,46)(H,47,48)(H4,34,35,36)/t23-,24-,25-,26-/m0/s1 InChIKey=CBRRRBFAHUNAGF-CQJMVLFOSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BIOPEP-UWM database of bioactive peptides (ID 8358), the MBPDB database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10054), the MBPDB database
Evidence 4 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
5