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Peptide record

TPDB01646

Antibacterial Antifungal Antioxidant Hemolysis Toxicity standard

3 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB01646

Activity

Antibacterial Antifungal Antioxidant Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides Functional / health-promoting peptides

Database_Source

Peptipedia CAFPdb dbAMP AnOxPePred - 1.0 AODB Multi-AOP PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (Antibacterial, Antifungal, Antioxidant, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.

Sequence

RWR

FASTA

>TPDB01646|Antibacterial;Antifungal;Antioxidant;Hemolysis;Toxicity|length=3
RWR

Formula C23H36N10O4

Absent Amino Acids ANDCEQGHILKMFPSTYV

Common Amino Acids R

Mass 516.60

PI 12.40

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +2

Boman Index -0.23

Hydrophobicity -3.300

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 1064.65

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

Formula

C23H36N10O4

Mass

516.60

12.40

Net Charge

Boman Index

-0.23

Hydrophobicity

-3.300

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against S. aureus MRSA 155 isolates (2-4 ug/ml), including vancomycin-resistant strains. MBC is slightly higher, indicating bacterial killing.

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against S. aureus MRSA 155 isolates (2-4 ug/ml), including vancomycin-resistant strains. MBC is slightly higher, indicating bacterial killing.

Evidence 3 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 64 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021

Evidence 4 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >256 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >256 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021

Evidence 5 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 32 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021

Evidence 6 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 64 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Eur J Med Chem | 2021

Evidence 7 Activity

Activity

Activity Endpoint 9.11% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 512 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

9.11% Hemolysis | 512 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Assessment of New Strategies to Improve the Performance of Antimicrobial Peptides | Nanomaterials (Basel) | 2022

Evidence 8 Activity

Activity

Activity Endpoint 62% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 512 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

62% Cytotoxicity | 512 | µg/mL | target cell: Mouse fibroblasts L929

Target

Target Cell Mouse fibroblasts L929

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Assessment of New Strategies to Improve the Performance of Antimicrobial Peptides | Nanomaterials (Basel) | 2022

Evidence 9 Activity

Activity

Activity Endpoint 62% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 512 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

62% Cytotoxicity | 512 | µg/mL | target cell: Baby Hamster Kidney cells BHK-21

Target

Target Cell Baby Hamster Kidney cells BHK-21

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Assessment of New Strategies to Improve the Performance of Antimicrobial Peptides | Nanomaterials (Basel) | 2022

Evidence 10 Activity

Activity

Activity Endpoint 5.27% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 512 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5.27% Hemolysis | 512 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Assessment of New Strategies to Improve the Performance of Antimicrobial Peptides | Nanomaterials (Basel) | 2022

Evidence 11 Activity

Activity

Activity Endpoint 22% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 512 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

22% Cytotoxicity | 512 | µg/mL | target cell: Mouse fibroblasts L929

Target

Target Cell Mouse fibroblasts L929

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Assessment of New Strategies to Improve the Performance of Antimicrobial Peptides | Nanomaterials (Basel) | 2022

Evidence 12 Activity

Activity

Activity Endpoint 25% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 512 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

25% Cytotoxicity | 512 | µg/mL | target cell: Baby Hamster Kidney cells BHK-21

Target

Target Cell Baby Hamster Kidney cells BHK-21

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Assessment of New Strategies to Improve the Performance of Antimicrobial Peptides | Nanomaterials (Basel) | 2022

Evidence 13 Activity

Activity

Activity Endpoint 0.35% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0.35% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial Peptides Incorporating Halogenated Marine-Derived Amino Acid Substituents. | ACS Med Chem Lett | 2023

Evidence 14 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >256 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Non hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents. | Bioorg Med Chem Lett | 2013

Evidence 15 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis