Peptide record

TPDB01636

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Antifungal Antihypertensive Antioxidant Antiviral Hemolysis Toxicity iDPPIV standard

2 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB01636

Peptide_Name

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

ACE inhibitors Antibacterial Antifungal Antihypertensive Antioxidant Antiviral Hemolysis Toxicity iDPPIV

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides Functional / health-promoting peptides

Database_Source

Peptipedia CAFPdb dbAMP AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP PD_Hemolysis iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.

Sequence

FASTA

>TPDB01636|ACE inhibitors;Antibacterial;Antifungal;Antihypertensive;Antioxidant;Antiviral;Hemolysis;Toxicity;iDPPIV|length=2
RW

Formula C17H24N6O3

Absent Amino Acids ANDCEQGHILKMFPSTYV

Common Amino Acids RW

Mass 360.42

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +1

Boman Index -1.04

Hydrophobicity -2.700

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 1526.01

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

Formula

C17H24N6O3

Mass

360.42

11.05

Net Charge

Boman Index

-1.04

Hydrophobicity

-2.700

Chemical_Mass

360.4099

Monoisotopic_Mass

360.1905

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 16.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02.001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.

Title Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980

Year 1980

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)O InChI=1S/C17H24N6O3/c18-12(5-3-7-21-17(19)20)15(24)23-14(16(25)26)8-10-9-22-13-6-2-1-4-11(10)13/h1-2,4,6,9,12,14,22H,3,5,7-8,18H2,(H,23,24)(H,25,26)(H4,19,20,21)/t12-,14-/m0/s1 InChIKey=QADCERNTBWTXFV-JSGCOSHPSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8214) Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9477) the BRENDA database Inhibitor of Dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID: 8890) Antiviral peptide according to the AVPdb database Inhibitor of Xanthine oxidase (EC 1.17.3.2) according to the EROP-Moscow database Information concerning angiotensin-converting enzyme is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001)

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 16.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02.001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.

Title Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980

Year 1980

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 2

Additional Info

Evidence 3 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB

Source DFBP

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The pharmacophore of short cationic antibacterial peptides. | J Med Chem | 2003

Evidence 5 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 8900 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 8900 | µM | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Length effects in antimicrobial peptides of the (RW)n series | Antimicrob Agents Chemother | 2007

Evidence 6 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement <<12.5 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | <<12.5 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Small lipopeptides possess anti-biofilm capability comparable to daptomycin and vancomycin. | RSC Adv | 2015

Evidence 7 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 0.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.

Title Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)O InChI=1S/C17H24N6O3/c18-12(5-3-7-21-17(19)20)15(24)23-14(16(25)26)8-10-9-22-13-6-2-1-4-11(10)13/h1-2,4,6,9,12,14,22H,3,5,7-8,18H2,(H,23,24)(H,25,26)(H4,19,20,21)/t12-,14-/m0/s1 InChIKey=QADCERNTBWTXFV-JSGCOSHPSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8214) Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02.001) according to the AHTPDB database the BindingDB database BIOPEP-UWM database of bioactive peptides (ID:7580) the ChEMBL database the EROP-Moscow database Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9521) the BRENDA database Antiviral peptide according to the AVPdb database Inhibitor of Xanthine oxidase (EC 1.17.3.2) according to the EROP-Moscow database Information concerning Dipeptidyl peptidase IV (DPP IV) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: S09.003)

Evidence 8 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis

Number_of_Residues