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Peptide record

TPDB01628

[Hyp3]-bradykinin Bradykinin Antibacterial Antifungal Antioxidant Antiparasitic Neuropeptide Toxicity standard

9 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB01628

Peptide_Name

[Hyp3]-bradykinin Bradykinin

Activity

Antibacterial Antifungal Antioxidant Antiparasitic Neuropeptide Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides Neuroactive peptides Functional / health-promoting peptides

Database_Source

AntiBP3 Peptipedia CAFPdb dbAMP AnOxPePred - 1.0 AoXpDb Multi-AOP i2APP ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Antibacterial, Antifungal, Antioxidant, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.

Sequence

RPPGFSPFR

FASTA

>TPDB01628|Antibacterial;Antifungal;Antioxidant;Antiparasitic;Neuropeptide;Toxicity|length=9
RPPGFSPFR

Formula C50H73N15O11

Absent Amino Acids ANDCEQHILKMTWYV

Common Amino Acids P

Mass 1060.22

PI 12.40

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +2

Boman Index 0.85

Hydrophobicity -1.044

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C50H73N15O11

Mass

1060.22

12.40

Net Charge

Boman Index

0.85

Hydrophobicity

-1.044

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against parasite P. gallinaceum ( Silva et al., 2015 ). Sequence updated 12/2/2013 updated activity 7/2019.

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against parasite P. gallinaceum ( Silva et al., 2015 ). Sequence updated 12/2/2013 updated activity 7/2019.

Evidence 3 Activity

Activity

Detail Source Activity Antiparasitic

Source & Reference

Database Source NA

Other

Evidence Text

Active against parasite P. gallinaceum ( Silva et al., 2015 ). Sequence updated 12/2/2013 updated activity 7/2019.

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pithecopus azureus

Family Bradykinin-related peptide

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Nephila clavipes

Family Bradykinin-related peptide

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ascaphus truei

Family Bradykinin-related peptide

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bombina orientalis

Family Bradykinin-related peptide

Evidence 8 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pelophylax ridibundus

Family Bradykinin-related peptide

Evidence 9 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Phasmahyla jandaia

Family Bradykinin-related peptide

Evidence 10 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pithecopus hypochondrialis

Family Bradykinin-related peptide

Evidence 11 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bombina maxima

Family Bradykinin-related peptide

Evidence 12 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Phyllomedusa sauvagei

Family Bradykinin-related peptide

Evidence 13 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Physalaemus nattereri

Family Bradykinin-related peptide

Evidence 14 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Bradykinin-related peptide

Evidence 15 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names B1 bradykinin receptor B2 bradykinin receptor

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Bradykinin-related peptide

Receptor Lengths 353 391

Receptor Ligands NP01635 NP01680 NP01684 NP01688 NP06028 NP01703 NP06313 NP01635 NP01680 NP01684 NP01688 NP06028 NP01703 NP06313

Evidence 16 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names B1 bradykinin receptor B2 bradykinin receptor

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Bradykinin-related peptide

Receptor Lengths 334 392

Receptor Ligands NP01636 NP01681 NP01685 NP01689 NP01636 NP01681 NP01685 NP01689

Evidence 17 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names B1 bradykinin receptor B2 bradykinin receptor

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Bradykinin-related peptide

Receptor Lengths 337 396

Receptor Ligands NP01637 NP01682 NP01686 NP01690 NP01637 NP01682 NP01686 NP01690

Evidence 18 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rana temporaria

Family Bradykinin-related peptide

Family

Bradykinin-related peptide

Receptor_Lengths

353 391 334 392 337 396

Receptor_Ligands

NP01635 NP01680 NP01684 NP01688 NP06028 NP01703 NP06313 NP01636 NP01681 NP01685 NP01689 NP01637 NP01682 NP01686 NP01690