TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB01567

Peptide_Name

ACE inhibitor from egg white

Activity

ACE inhibitors Antihypertensive Antioxidant Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

RADHPFL

FASTA

>TPDB01567|ACE inhibitors;Antihypertensive;Antioxidant;Neuropeptide|length=7
RADHPFL

Formula C39H58N12O10

Absent Amino Acids NCEQGIKMSTWYV

Common Amino Acids ARDHLFP

Mass 854.96

PI 7.85

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 3

Net Charge +0

Boman Index 1.59

Hydrophobicity -0.629

Aliphatic Index 70.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

1

R

0

N

1

D

0

C

0

E

0

Q

0

G

1

H

0

I

1

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C39H58N12O10

Mass

854.96

PI

7.85

Net Charge

+0

Boman Index

1.59

Hydrophobicity

-0.629

Chemical_Mass

854.9499

Monoisotopic_Mass

854.4386

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Babij K., Dąbrowska A., Szołtysik M., Pokora M., Zambrowicz A., Chrzanowska J.

Title

The Evaluation of Dipeptidyl Peptidase (DPP)-IV, a-Glucosidase and Angiotensin Converting Enzyme (ACE) Inhibitory Activities

Year 2014

Literature Source Journal

Other

Number of Residues 7

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Babij K., Dąbrowska A., Szołtysik M., Pokora M., Zambrowicz A., Chrzanowska J.

Title

The Evaluation of Dipeptidyl Peptidase (DPP)-IV, a-Glucosidase and Angiotensin Converting Enzyme (ACE) Inhibitory Activities

Year 2014

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 7

Evidence 3 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB AoXpDb

Source DFBP

Number_of_Residues

7