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Peptide record

TPDB01566

ACE inhibitors Antihypertensive Antioxidant Neuropeptide standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB01566
ACE inhibitors Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
pep-lab Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
RADHPF
Physicochemical Analysis
C33H47N11O9
NCEQGILKMSTWYV
ARDHFP
741.80
7.85
2
1
2
+0
2.15
-1.367
16.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
1
R
0
N
1
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C33H47N11O9
741.80
7.85
+0
2.15
-1.367
741.7927
741.3548
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Matoba N. et al.
A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery.FEBS Lett., 452, 181-184
1999
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C33H47N11O9/c1-18(40-28(48)21(34)9-5-11-38-33(35)36)27(47)41-22(15-26(45)46)29(49)42-23(14-20-16-37-17-39-20)31(51)44-12-6-10-25(44)30(50)43-24(32(52)53)13-19-7-3-2-4-8-19/h2-4,7-8,16-18,21-25H,5-6,9-15,34H2,1H3,(H,37,39)(H,40,48)(H,41,47)(H,42,49)(H,43,50)(H,45,46)(H,52,53)(H4,35,36,38)/t18-,21-,22-,23-,24-,25-/m0/s1 InChIKey=UPBCMRNBWQURFH-LHOYKQQOSA-N
Evidence 2 Activity

Activity

EC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Matoba N. et al.
A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery.FEBS Lett., 452, 181-184
1999
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C33H47N11O9/c1-18(40-28(48)21(34)9-5-11-38-33(35)36)27(47)41-22(15-26(45)46)29(49)42-23(14-20-16-37-17-39-20)31(51)44-12-6-10-25(44)30(50)43-24(32(52)53)13-19-7-3-2-4-8-19/h2-4,7-8,16-18,21-25H,5-6,9-15,34H2,1H3,(H,37,39)(H,40,48)(H,41,47)(H,42,49)(H,43,50)(H,45,46)(H,52,53)(H4,35,36,38)/t18-,21-,22-,23-,24-,25-/m0/s1 InChIKey=UPBCMRNBWQURFH-LHOYKQQOSA-N
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
6