TPDB

3D PDB MODEL

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TPDB ID TPDB01564

Peptide_Name

Arginine L-R R1

Activity

Antioxidant Bitter Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides Food sensory peptides Functional / health-promoting peptides

Database_Source

AODB Tastepeptides-Meta CPPsite3.0

Sequence_Type

standard

Has_Modification No

Description A 1-aa standard natural multi-activity (Antioxidant, Bitter, and Cell-penetrating Peptides) peptide sequence curated from AODB, Tastepeptides-Meta, and CPPsite3.0, with an available 3D structural model.

Sequence

R

FASTA

>TPDB01564|Antioxidant;Bitter;Cell-penetrating Peptides|length=1
R

Formula C6H14N4O2

Absent Amino Acids ANDCEQGHILKMFPSTWYV

Common Amino Acids R

Mass 174.20

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +1

Boman Index 0.81

Hydrophobicity -4.500

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

1

Formula

C6H14N4O2

Mass

174.20

PI

11.05

Net Charge

+1

Boman Index

0.81

Hydrophobicity

-4.500

C_terminal_Modification

Free

Chirality

L

Ionic_State

Cationic

Linearity

Linear

N_terminal_Modification

Free

SMILES

N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O

Evidence 1 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB

Source DFBP

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Rat Primary Cortical Cultures

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Uptake Mechanism Heparan sulfate receptor-mediated endocytic pathway

In Vitro or In Vivo In vitro

DSSP Secondary Structure C

Evidence 3 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Caco-2 Cells

Assay & Model

In Vitro Model Male Ddy mice weighing 30-40 g Ex-vivo ileum closed loop of Sprague Dawley rats weighing 180–220 g

In Vivo Model Male Ddy mice weighing 30-40 g Ex-vivo ileum closed loop of Sprague Dawley rats weighing 180–220 g

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Insulin

Uptake Efficiency L-arginine effectiveness was higher than that of D-arginine.

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CC

Evidence 4 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line ARPE-19 cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type 5-FITC dye

Subcellular Localization Cytoplasm

Uptake Efficiency Observed a cytoplasm filled with green fluorescence.

In Vitro or In Vivo In vitro

DSSP Secondary Structure CTTTTSCSSCCC

Evidence 5 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HUVECs

Assay & Model

In Vitro Model C57BL/6 mice

In Vivo Model C57BL/6 mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Ranibizumab (RBZ) and 5-FITC dye

Subcellular Localization Cytoplasm

Uptake Efficiency Observed a cytoplasm filled with green fluorescence.

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure C

Evidence 6 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HUVECs

Assay & Model

In Vitro Model C57BL/6 mice

In Vivo Model C57BL/6 mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Conbercept (CBC) and 5-FITC dye

Subcellular Localization Cytoplasm

Uptake Efficiency Observed a cytoplasm filled with green fluorescence.

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure C

DSSP_Secondary_Structure

C CC CTTTTSCSSCCC