TPDB

3D PDB MODEL

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TPDB ID TPDB01534

Peptide_Name

Anti-inflammatory peptide

Activity

Anti-inflammatory Antioxidant

Activity_category_statistics

Immunity and inflammation peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Anti-inflammatory and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

QNWDFCEAWEPCF

FASTA

>TPDB01534|Anti-inflammatory;Antioxidant|length=13
QNWDFCEAWEPCF

Formula C77H95N17O22S2

Absent Amino Acids RGHILKMSTYV

Common Amino Acids CEFW

Mass 1674.82

PI 2.94

Basic Residues 0

Acidic Residues 3

Hydrophobic Residues 5

Net Charge -3

Boman Index 0.11

Hydrophobicity -0.654

Aliphatic Index 7.69

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 11125

Absorbance 280nm 664.25

Polar Residues 4

number

1

A

0

R

1

N

1

D

2

C

2

E

1

Q

0

G

0

H

0

I

0

L

0

K

0

M

2

F

1

P

0

S

0

T

2

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 1 C: 2 E: 2 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 1 S: 0 T: 0 W: 2 Y: 0 V: 0

Length

13

Formula

C77H95N17O22S2

Mass

1674.82

PI

2.94

Net Charge

-3

Boman Index

0.11

Hydrophobicity

-0.654

Chemical_Mass

1674.8073

Monoisotopic_Mass

1673.6257

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Anti-inflammatory

Activity Measurement 0.00 µM

Detail Activity anti inflammatory

Activity Code ai

Source & Reference

Database Source NA

Authors Hu S., Yuan J., Gao J., Wu Y., Meng X., Tong P., Chen H.

Title

Antioxidant and Anti-Inflammatory Potential of Peptides Derived from In Vitro Gastrointestinal Digestion of Germinated and Heat-Treated Foxtail Millet (Setaria italica) Proteins, J. Agric. Food Chem., 68(35), 9415–9426, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 13

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC4=C[N]([H])C5=CC=CC=C45)C(=O)N[C@@H](CCC(=O)O)C(=O)N6[C@@H](CCC6)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC7=CC=CC=C7)C(=O)O InChI=1S/C77H95N17O22S2/c1-39(65(103)86-52(31-42-35-81-47-19-10-8-17-44(42)47)69(107)85-50(24-27-63(99)100)76(114)94-28-12-21-59(94)75(113)93-58(38-118)74(112)91-56(77(115)116)30-41-15-6-3-7-16-41)83-67(105)49(23-26-62(97)98)84-73(111)57(37-117)92-68(106)51(29-40-13-4-2-5-14-40)88-72(110)55(34-64(101)102)90-70(108)53(32-43-36-82-48-20-11-9-18-45(43)48)89-71(109)54(33-61(80)96)87-66(104)46(78)22-25-60(79)95/h2-11,13-20,35-36,39,46,49-59,81-82,117-118H,12,21-34,37-38,78H2,1H3,(H2,79,95)(H2,80,96)(H,83,105)(H,84,111)(H,85,107)(H,86,103)(H,87,104)(H,88,110)(H,89,109)(H,90,108)(H,91,112)(H,92,106)(H,93,113)(H,97,98)(H,99,100)(H,101,102)(H,115,116)/t39-,46-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-/m0/s1 InChIKey: CVLJFQVQMLWIAZ-NILQTWPUSA-N

Number_of_Residues

13