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Peptide record

TPDB01484

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB01484
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AODB
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
PYK
Physicochemical Analysis
C20H30N4O5
ARNDCEQGHILMFSTWV
KPY
406.48
9.74
1
0
1
+1
0.50
-2.267
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
366.56
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
3
C20H30N4O5
406.48
9.74
+1
0.50
-2.267
406.4748
406.2209
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Fan H., Wang J., Liao W., Jiang J., Wu J.
Identification and characterization of gastrointestinal-resistant angiotensin-converting enzyme inhibitory peptides from egg white proteins. J. Agric. Food Chem., 67, 7147−7156, 2019
2019
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: C1C[C@H](NC1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCCCN)C(=O)O InChI=1S/C20H30N4O5/c21-10-2-1-4-16(20(28)29)23-19(27)17(12-13-6-8-14(25)9-7-13)24-18(26)15-5-3-11-22-15/h6-9,15-17,22,25H,1-5,10-12,21H2,(H,23,27)(H,24,26)(H,28,29)/t15-,16-,17-/m0/s1 InChIKey=UIUWGMRJTWHIJZ-ULQDDVLXSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Fan H., Wang J., Liao W., Jiang J., Wu J.
Identification and characterization of gastrointestinal-resistant angiotensin-converting enzyme inhibitory peptides from egg white proteins. J. Agric. Food Chem., 67, 7147−7156, 2019
2019
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: C1C[C@H](NC1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCCCN)C(=O)O InChI=1S/C20H30N4O5/c21-10-2-1-4-16(20(28)29)23-19(27)17(12-13-6-8-14(25)9-7-13)24-18(26)15-5-3-11-22-15/h6-9,15-17,22,25H,1-5,10-12,21H2,(H,23,27)(H,24,26)(H,28,29)/t15-,16-,17-/m0/s1 InChIKey=UIUWGMRJTWHIJZ-ULQDDVLXSA-N
Additional Detail Fields 1 fields
3