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Peptide record

TPDB01434

ACE inhibitor from porcine myosin (981-983) ACE inhibitors Antihypertensive Antioxidant Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB01434
ACE inhibitor from porcine myosin (981-983)
ACE inhibitors Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
FermFooDB Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PPK
Physicochemical Analysis
C16H28N4O4
ARNDCEQGHILMFSTWYV
P
340.42
10.10
1
0
0
+1
1.89
-2.367
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C16H28N4O4
340.42
10.10
+1
1.89
-2.367
340.4168
340.2104
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1001.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Arihara K., Nakashima Y., Mukai T., Ishikawa S., Itoh M.
Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle proteins. Meat Sci., 57, 319-324, 2001
2001
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C16H28N4O4/c17-8-2-1-5-12(16(23)24)19-14(21)13-7-4-10-20(13)15(22)11-6-3-9-18-11/h11-13,18H,1-10,17H2,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1 InChIKey=PCWLNNZTBJTZRN-AVGNSLFASA-N Antithrombotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8168) Antioxidative peptide according to the FermFooDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
1001.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Arihara K., Nakashima Y., Mukai T., Ishikawa S., Itoh M.
Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle proteins. Meat Sci., 57, 319-324, 2001
2001
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C16H28N4O4/c17-8-2-1-5-12(16(23)24)19-14(21)13-7-4-10-20(13)15(22)11-6-3-9-18-11/h11-13,18H,1-10,17H2,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1 InChIKey=PCWLNNZTBJTZRN-AVGNSLFASA-N Antithrombotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8168) Antioxidative peptide according to the FermFooDB database
Additional Detail Fields 1 fields
3