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Peptide record

TPDB01430

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Anticancer Antihypertensive Antioxidant Bitter Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB01430
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antibacterial Anticancer Antihypertensive Antioxidant Bitter Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Food sensory peptides Functional / health-promoting peptides
FermFooDB Peptipedia AHTPDB AnOxPePred - 1.0 AODB Multi-AOP Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PP
Physicochemical Analysis
C10H16N2O3
ARNDCEQGHILKMFSTWYV
P
212.25
6.02
0
0
0
-0
0.90
-1.600
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C10H16N2O3
212.25
6.02
-0
0.90
-1.600
212.2450
212.1157
Evidence Records 5 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: C1C[C@@H](C(=O)N2CCC[C@H]2C(=O)O)NC1 InChI=1S/C10H16N2O3/c13-9(7-3-1-5-11-7)12-6-2-4-8(12)10(14)15/h7-8,11H,1-6H2,(H,14,15)/t7-,8-/m0/s1 InChIKey: RWCOTTLHDJWHRS-YUMQZZPRSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3170), the EROP-Moscow database (ID E09232) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9651) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids.
Evidence 2 Activity

Activity

EC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: C1C[C@@H](C(=O)N2CCC[C@H]2C(=O)O)NC1 InChI=1S/C10H16N2O3/c13-9(7-3-1-5-11-7)12-6-2-4-8(12)10(14)15/h7-8,11H,1-6H2,(H,14,15)/t7-,8-/m0/s1 InChIKey: RWCOTTLHDJWHRS-YUMQZZPRSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3170), the EROP-Moscow database (ID E09232) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9651) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids.
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB FermFooDB
DFBP
Evidence 4 Activity

Activity

IC50
Toxicity
0.48±0.11 µM
Cytotoxic
IC50 | 0.48±0.11 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. | J Med Chem | 2012
Evidence 5 Activity

Activity

IC50
iDPPIV
5860.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Hatanaka T., Inoue Y., Arima J., Kumagai Y., Usuki H., Kawakami K., Kimura M., Mukaihara T.
Production of dipeptidyl peptidase IV inhibitory peptides from defated rice bran. Food Chem., 134, 797-802
2012
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: C1C[C@@H](C(=O)N2CCC[C@H]2C(=O)O)NC1 InChI=1S/C10H16N2O3/c13-9(7-3-1-5-11-7)12-6-2-4-8(12)10(14)15/h7-8,11H,1-6H2,(H,14,15)/t7-,8-/m0/s1 InChIKey: RWCOTTLHDJWHRS-YUMQZZPRSA-N First reference concerning peptide: Yoshimoto T., Fischl M., Orlowski R. C., Walter R., 1978, Post-proline cleaving enzyme and post-proline dipeptidyl aminopeptidase: comparison of two peptidases with high specificity for proline residues. J. Biol. Chem., 253, 3708-3716 Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BIOPEP-UWM database of bioactive peptides (ID 7836) the EROP-Moscow database (ID E01865) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9651) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids.
Additional Detail Fields 1 fields
2