TPDB

3D PDB MODEL

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TPDB ID TPDB01366

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AnOxPePred - 1.0 AODB Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AnOxPePred - 1.0, AODB, and other sources, with an available 3D structural model.

Sequence

PDLVF

FASTA

>TPDB01366|ACE inhibitors;Antioxidant|length=5
PDLVF

Formula C29H43N5O8

Absent Amino Acids ARNCEQGHIKMSTWY

Common Amino Acids DLFPV

Mass 589.69

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index 0.06

Hydrophobicity 1.140

Aliphatic Index 136.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

5

Formula

C29H43N5O8

Mass

589.69

PI

3.10

Net Charge

-1

Boman Index

0.06

Hydrophobicity

1.140

Chemical_Mass

589.6787

Monoisotopic_Mass

589.3101

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 84.90 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Torkova A., Kononikhin A., Bugrova A., Khotchenkov V., Tsentalovich M., Medvedeva U.

Title

Effect of in vitro gastrointestinal digestion on bioactivity of poultry protein hydrolysate. Curr. Res. Nutr. Food Sci., 4 (SI 2), 77-86, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C29H43N5O8/c1-16(2)13-20(31-26(38)21(15-23(35)36)32-25(37)19-11-8-12-30-19)27(39)34-24(17(3)4)28(40)33-22(29(41)42)14-18-9-6-5-7-10-18/h5-7,9-10,16-17,19-22,24,30H,8,11-15H2,1-4H3,(H,31,38)(H,32,37)(H,33,40)(H,34,39)(H,35,36)(H,41,42)/t19-,20-,21-,22-,24-/m0/s1 InChIKey: ANQBFBSKIMYBNS-YGQNSOCVSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB

Source DFBP

Number_of_Residues

5