TPDB

3D PDB MODEL

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TPDB ID TPDB01352

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

NYVADGLG

FASTA

>TPDB01352|ACE inhibitors;Antioxidant|length=8
NYVADGLG

Formula C35H53N9O13

Absent Amino Acids RCEQHIKMFPSTW

Common Amino Acids G

Mass 807.86

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -1

Boman Index 0.07

Hydrophobicity 0.088

Aliphatic Index 97.50

Half Life

Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 184.44

Polar Residues 2

number

1

A

0

R

1

N

1

D

0

C

0

E

0

Q

2

G

0

H

0

I

1

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

8

Formula

C35H53N9O13

Mass

807.86

PI

3.10

Net Charge

-1

Boman Index

0.07

Hydrophobicity

0.088

Chemical_Mass

807.8457

Monoisotopic_Mass

807.3750

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 14.97 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zielińska E., Karaś M., Baraniak B., Jakubczyk A.

Title

Evaluation of ACE, alpha glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects. Eur. Food Res. Technol., 246, 1361-1369, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)O InChI=1S/C35H53N9O13/c1-16(2)10-22(32(54)39-15-28(50)51)41-26(47)14-38-33(55)24(13-27(48)49)42-30(52)18(5)40-35(57)29(17(3)4)44-34(56)23(11-19-6-8-20(45)9-7-19)43-31(53)21(36)12-25(37)46/h6-9,16-18,21-24,29,45H,10-15,36H2,1-5H3,(H2,37,46)(H,38,55)(H,39,54)(H,40,57)(H,41,47)(H,42,52)(H,43,53)(H,44,56)(H,48,49)(H,50,51)/t18-,21-,22-,23-,24-,29-/m0/s1 InChIKey=RUDICKKMQRBXRT-LXFJOMDISA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9440) Pancreatic lipase inhibitor according to the BIOPEP-UWM database of bioactive peptides (ID 9827) Inhibitor of Alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9828)

Number_of_Residues

8