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Peptide record

TPDB01277

ACE inhibitor ACE inhibitors Anticancer Antioxidant standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB01277
ACE inhibitor
ACE inhibitors Anticancer Antioxidant
Cardiometabolic peptides Cancer-related peptides Functional / health-promoting peptides
Peptipedia dbACP AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Anticancer, and Antioxidant) peptide sequence curated from Peptipedia, dbACP, AnOxPePred - 1.0, and other sources, with an available 3D structural model.
Sequence
MTEEY
Physicochemical Analysis
C28H41N5O12S1
ARNDCQGHILKFPSWV
E
671.72
3.13
0
2
2
-2
3.01
-1.420
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
221.82
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
2
E
0
Q
0
G
0
H
0
I
0
L
0
K
1
M
0
F
0
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
5
C28H41N5O12S1
671.72
3.13
-2
3.01
-1.420
671.7159
671.2462
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
90.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Luna-Vital D. A., Gonzalez de Mejia E., Mendoza S., Loarca-Pina G.
Peptides present in the non-digestible fraction of common beans (Phaseolus vulgaris L.) inhibit the angiotensin-I converting enzyme by interacting with its catalytic cavity independent of their antioxidant capacity. Food Funct., 6, 1470-1479, 2015
2015
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C28H41N5O12S/c1-14(34)23(33-24(40)17(29)11-12-46-2)27(43)31-19(8-10-22(38)39)25(41)30-18(7-9-21(36)37)26(42)32-20(28(44)45)13-15-3-5-16(35)6-4-15/h3-6,14,17-20,23,34-35H,7-13,29H2,1-2H3,(H,30,41)(H,31,43)(H,32,42)(H,33,40)(H,36,37)(H,38,39)(H,44,45)/t14?,17-,18-,19-,20-,23-/m0/s1 InChIKey: AQODTKFHGCQVPE-JWVZIVEMSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9100)
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
5