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Peptide record

TPDB01251

ACE inhibitor from beta-Lg (fr. 7-9) – Wheylin-2 ACE inhibitors Antihypertensive Antioxidant Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB01251
ACE inhibitor from beta-Lg (fr. 7-9) – Wheylin-2
ACE inhibitors Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
MKG
Physicochemical Analysis
C13H26N4O4S1
ARNDCEQHILFPSTWYV
GKM
334.43
10.10
1
0
1
+1
0.77
-0.800
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
1
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C13H26N4O4S1
334.43
10.10
+1
0.77
-0.800
334.4350
334.1669
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
71.85 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Hernández-Ledesma B., Ramos M., Recio I., Amigo L.
Effect of beta-lactoglobulin hydrolysis with thermolysin under denaturing temperatures on the release of bioactive peptides. J. Chromatogr. A, 1116, 31-37, 2006
2006
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)O InChI=1S/C13H26N4O4S/c1-22-7-5-9(15)12(20)17-10(4-2-3-6-14)13(21)16-8-11(18)19/h9-10H,2-8,14-15H2,1H3,(H,16,21)(H,17,20)(H,18,19)/t9-,10-/m0/s1 InChIKey=AXHNAGAYRGCDLG-UWVGGRQHSA-N Anxiolytic-like peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10112)
Evidence 2 Activity

Activity

IC50
Antihypertensive
71.85 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Hernández-Ledesma B., Ramos M., Recio I., Amigo L.
Effect of beta-lactoglobulin hydrolysis with thermolysin under denaturing temperatures on the release of bioactive peptides. J. Chromatogr. A, 1116, 31-37, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)O InChI=1S/C13H26N4O4S/c1-22-7-5-9(15)12(20)17-10(4-2-3-6-14)13(21)16-8-11(18)19/h9-10H,2-8,14-15H2,1H3,(H,16,21)(H,17,20)(H,18,19)/t9-,10-/m0/s1 InChIKey=AXHNAGAYRGCDLG-UWVGGRQHSA-N Anxiolytic-like peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10112)
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
3