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Peptide record

TPDB01167

ACE inhibitor from soybean Anti-inflammatory peptide ACE inhibitors Anti-inflammatory Antihypertensive Antioxidant standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB01167
ACE inhibitor from soybean Anti-inflammatory peptide
ACE inhibitors Anti-inflammatory Antihypertensive Antioxidant
Cardiometabolic peptides Immunity and inflammation peptides Functional / health-promoting peptides
Peptipedia AHTPDB Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Anti-inflammatory, Antihypertensive, and other sources) peptide sequence curated from Peptipedia, AHTPDB, and Multi-AOP, with an available 3D structural model.
Sequence
LSW
Physicochemical Analysis
C20H28N4O5
ARNDCEQGHIKMFPTYV
LSW
404.47
6.02
0
0
2
-0
-2.28
0.700
130.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
1359.82
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C20H28N4O5
404.47
6.02
-0
-2.28
0.700
404.4590
404.2053
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
2.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Gu Y., Wu J.
LC–MS/MS coupled with QSAR modeling in characterising of angiotensin I-converting enzyme inhibitory peptides from soybean proteins. Food Chemistry 141, 2682–2690, doi:10.1016/j.foodchem.2013.04.064.
2013
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C20H28N4O5/c1-11(2)7-14(21)18(26)24-17(10-25)19(27)23-16(20(28)29)8-12-9-22-15-6-4-3-5-13(12)15/h3-6,9,11,14,16-17,22,25H,7-8,10,21H2,1-2H3,(H,23,27)(H,24,26)(H,28,29)/t14-,16-,17-/m0/s1 InChIKey= HWMQRQIFVGEAPH-XIRDDKMYSA-N
Evidence 2 Activity

Activity

EC50
Anti-inflammatory
0.00 µM
Anti-inflammatory
anti inflammatory
ai

Source & Reference

NA
Fan H., Bhullar K.S., Wang Z., Wu J.
Soybean-Derived Tripeptide Leu–Ser–Trp (LSW) Protects Human Vascular Endothelial Cells from TNFα-Induced Oxidative Stress and Inflammation via Modulating TNFα Receptors and SIRT1. Foods 11 (22), 2022
2022
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C20H28N4O5/c1-11(2)7-14(21)18(26)24-17(10-25)19(27)23-16(20(28)29)8-12-9-22-15-6-4-3-5-13(12)15/h3-6,9,11,14,16-17,22,25H,7-8,10,21H2,1-2H3,(H,23,27)(H,24,26)(H,28,29)/t14-,16-,17-/m0/s1 InChIKey= HWMQRQIFVGEAPH-XIRDDKMYSA-N
Evidence 3 Activity

Activity

IC50
Antihypertensive
2.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Gu Y., Wu J.
LC–MS/MS coupled with QSAR modeling in characterising of angiotensin I-converting enzyme inhibitory peptides from soybean proteins. Food Chemistry 141, 2682–2690, doi:10.1016/j.foodchem.2013.04.064.
2013
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C20H28N4O5/c1-11(2)7-14(21)18(26)24-17(10-25)19(27)23-16(20(28)29)8-12-9-22-15-6-4-3-5-13(12)15/h3-6,9,11,14,16-17,22,25H,7-8,10,21H2,1-2H3,(H,23,27)(H,24,26)(H,28,29)/t14-,16-,17-/m0/s1 InChIKey= HWMQRQIFVGEAPH-XIRDDKMYSA-N
Additional Detail Fields 1 fields
3