TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB01164

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

LSNGK

FASTA

>TPDB01164|ACE inhibitors;Antioxidant|length=5
LSNGK

Formula C21H39N7O8

Absent Amino Acids ARDCEQHIMFPTWYV

Common Amino Acids NGLKS

Mass 517.58

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +1

Boman Index 0.99

Hydrophobicity -0.960

Aliphatic Index 78.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

1

K

0

M

0

F

0

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C21H39N7O8

Mass

517.58

PI

10.10

Net Charge

+1

Boman Index

0.99

Hydrophobicity

-0.960

Chemical_Mass

517.5749

Monoisotopic_Mass

517.2851

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 130.60 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Luna-Vital D. A., Gonzalez de Mejia E., Mendoza S., Loarca-Pina G.

Title

Peptides present in the non-digestible fraction of common beans (Phaseolus vulgaris L.) inhibit the angiotensin-I converting enzyme by interacting with its catalytic cavity independent of their antioxidant capacity. Food Funct., 6, 1470-1479, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C21H39N7O8/c1-11(2)7-12(23)18(32)28-15(10-29)20(34)27-14(8-16(24)30)19(33)25-9-17(31)26-13(21(35)36)5-3-4-6-22/h11-15,29H,3-10,22-23H2,1-2H3,(H2,24,30)(H,25,33)(H,26,31)(H,27,34)(H,28,32)(H,35,36)/t12-,13-,14-,15-/m0/s1 InChIKey: JHQFEFOCJCVJCJ-AJNGGQMLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9102)

Number_of_Residues

5