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Peptide record

TPDB01142

ACE inhibitor from k-CN (fr. 56-60) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Antioxidant iDPPIV standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB01142
ACE inhibitor from k-CN (fr. 56-60) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Antioxidant iDPPIV
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AODB Multi-AOP iDPPIV
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
LPYPY
Physicochemical Analysis
C34H45N5O8
ARNDCEQGHIKMFSTWV
PY
651.76
5.88
0
0
3
-0
-1.54
-0.400
78.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
2980
457.22
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
5
C34H45N5O8
651.76
5.88
-0
-1.54
-0.400
651.7480
651.3257
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
28.90 µM
ACE inhibitor
ah

Source & Reference

NA
Gomez-Ruiz J. A., Ramos M., Recio I.
Identification of novel angiotensin-converting enzyme-inhibitory peptides from ovine milk proteins by CE-MS and chromatographic techniques. Electrophoresis, 28, 4202-4211.
2007
Journal

Other

5
Evidence 2 Activity

Activity

IC50
Antihypertensive
28.90 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Gomez-Ruiz J. A., Ramos M., Recio I.
Identification of novel angiotensin-converting enzyme-inhibitory peptides from ovine milk proteins by CE-MS and chromatographic techniques. Electrophoresis, 28, 4202-4211.
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Evidence 4 Activity

Activity

IC50
iDPPIV
108.30 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., FitzGerald R. J.
Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chemistry 145, 845-852
2014
Journal

Other

5
Also as ACE inhibitor (BIOPEP ID 7631)
Additional Detail Fields 1 fields
5