TPDB

3D PDB MODEL

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TPDB ID TPDB01133

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

LPILR

FASTA

>TPDB01133|ACE inhibitors;Antioxidant|length=5
LPILR

Formula C29H54N8O6

Absent Amino Acids ANDCEQGHKMFSTWYV

Common Amino Acids L

Mass 610.80

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index -0.17

Hydrophobicity 1.200

Aliphatic Index 234.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

2

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C29H54N8O6

Mass

610.80

PI

11.05

Net Charge

+1

Boman Index

-0.17

Hydrophobicity

1.200

Chemical_Mass

610.7869

Monoisotopic_Mass

610.4154

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 779.80 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zheng Y., Li Y., Zhang Y., Ruan X., Zhang R.

Title

Purification, characterization, synthesis, in vitro ACE inhibition andin vivo antihypertensive activity of bioactive peptides derived from oilpalm kernel glutelin-2 hydrolysates. J. Funct. Foods, 28, 48-58, 2017

Year 2017

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C29H54N8O6/c1-7-18(6)23(36-25(39)22-11-9-13-37(22)27(41)19(30)14-16(2)3)26(40)35-21(15-17(4)5)24(38)34-20(28(42)43)10-8-12-33-29(31)32/h16-23H,7-15,30H2,1-6H3,(H,34,38)(H,35,40)(H,36,39)(H,42,43)(H4,31,32,33)/t18-,19-,20-,21-,22-,23-/m0/s1 InChIKey: PZQROTRLSJRAOA-LLINQDLYSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8661) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9716)

Number_of_Residues

5