TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB01109

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant iDPPIV

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (ACE inhibitors, Antioxidant, and iDPPIV) peptide sequence curated from Peptipedia, AODB, and iDPPIV, with an available 3D structural model.

Sequence

LLY

FASTA

>TPDB01109|ACE inhibitors;Antioxidant;iDPPIV|length=3
LLY

Formula C21H33N3O5

Absent Amino Acids ARNDCEQGHIKMFPSTWV

Common Amino Acids L

Mass 407.51

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -2.06

Hydrophobicity 2.100

Aliphatic Index 260.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 365.64

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

2

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

3

Formula

C21H33N3O5

Mass

407.51

PI

5.94

Net Charge

-0

Boman Index

-2.06

Hydrophobicity

2.100

Chemical_Mass

407.5025

Monoisotopic_Mass

407.2412

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Sowmya K., Mala D., Bhat M. I., Bajaj R. K., R., Kapila S., Kapila R.

Title

Bio-accessible milk casein derived tripeptide (LLY) mediates overlapping anti- inflammatory and anti-oxidative effects under cellular (Caco-2) and in vivo milieu. J. Nutr. Biochem., 62, 167-180, 2018

Year 2018

Literature Source Journal

Other

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C21H33N3O5/c1-12(2)9-16(22)19(26)23-17(10-13(3)4)20(27)24-18(21(28)29)11-14-5-7-15(25)8-6-14/h5-8,12-13,16-18,25H,9-11,22H2,1-4H3,(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1 InChIKey=UCNNZELZXFXXJQ-BZSNNMDCSA-N Immunostimulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3065), the EROP-Moscow database the MBPDB database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10168) the MBPDB database Antiviral peptide according to the BIOPEP-UWM Virtual database (ID 57)

Number_of_Residues

3