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Peptide record

TPDB01086

ACE inhibitor from caprine beta-Lg Antihypertensive peptide ACE inhibitors Antihypertensive Antioxidant Bitter standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB01086
ACE inhibitor from caprine beta-Lg Antihypertensive peptide
ACE inhibitors Antihypertensive Antioxidant Bitter
Cardiometabolic peptides Food sensory peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP Tastepeptides-Meta
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
LLF
Physicochemical Analysis
C21H33N3O4
ARNDCEQGHIKMPSTWYV
L
391.51
6.02
0
0
3
-0
-2.25
3.467
260.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C21H33N3O4
391.51
6.02
-0
-2.25
3.467
391.5031
391.2463
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
79.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Hernández-Ledesma B., Recio I., Ramos M., Amigo L.
Preparation of ovine and caprine β-lactoglobulin hydrolysates with ACE-inhibitory activity. Identification of active peptides from caprine β-lactoglobulin hydrolysed with thermolysin. Int. Dairy J., 12, 805-812, 2002
2002
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O InChI=1S/C21H33N3O4/c1-13(2)10-16(22)19(25)23-17(11-14(3)4)20(26)24-18(21(27)28)12-15-8-6-5-7-9-15/h5-9,13-14,16-18H,10-12,22H2,1-4H3,(H,23,25)(H,24,26)(H,27,28)/t16-,17-,18-/m0/s1 InChIKey=UBZGNBKMIJHOHL-BZSNNMDCSA-N Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 500) the EROP-Moscow database
Evidence 2 Activity

Activity

IC50
Antihypertensive
79.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Hernández-Ledesma B., Recio I., Ramos M., Amigo L.
Preparation of ovine and caprine β-lactoglobulin hydrolysates with ACE-inhibitory activity. Identification of active peptides from caprine β-lactoglobulin hydrolysed with thermolysin. Int. Dairy J., 12, 805-812, 2002
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O InChI=1S/C21H33N3O4/c1-13(2)10-16(22)19(25)23-17(11-14(3)4)20(26)24-18(21(27)28)12-15-8-6-5-7-9-15/h5-9,13-14,16-18H,10-12,22H2,1-4H3,(H,23,25)(H,24,26)(H,27,28)/t16-,17-,18-/m0/s1 InChIKey=UBZGNBKMIJHOHL-BZSNNMDCSA-N Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 500) the EROP-Moscow database
Evidence 3 Activity

Activity

IC50
Antihypertensive
0.00 µM
Lowering blood pressure in rats
hypotensive
hyp

Source & Reference

AHTPDB
Hernández-Ledesma B., Miguel M., Amigo L., Aleixandre M. A., Recio I.
Effect of simulated gastrointestinal digestion on the antihypertensive properties of synthetic beta-lactoglobulin peptide sequences. J. Dairy Res., 74, 336-339, 2007
2007
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O InChI=1S/C21H33N3O4/c1-13(2)10-16(22)19(25)23-17(11-14(3)4)20(26)24-18(21(27)28)12-15-8-6-5-7-9-15/h5-9,13-14,16-18H,10-12,22H2,1-4H3,(H,23,25)(H,24,26)(H,27,28)/t16-,17-,18-/m0/s1 InChIKey=UBZGNBKMIJHOHL-BZSNNMDCSA-N Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 500) the EROP-Moscow database Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 7807) the DFBP database
Evidence 4 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
3