TPDB

3D PDB MODEL

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TPDB ID TPDB01078

Peptide_Name

ACE inhibitor from thornback ray muscle (Raja clavata)

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

pep-lab Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from pep-lab, Peptipedia, AODB, and other sources, with an available 3D structural model.

Sequence

LKYPI

FASTA

>TPDB01078|ACE inhibitors;Antioxidant|length=5
LKYPI

Formula C32H52N6O7

Absent Amino Acids ARNDCEQGHMFSTWV

Common Amino Acids ILKPY

Mass 632.80

PI 9.74

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index -0.37

Hydrophobicity 0.300

Aliphatic Index 156.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 235.46

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

1

L

1

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

5

Formula

C32H52N6O7

Mass

632.80

PI

9.74

Net Charge

+1

Boman Index

-0.37

Hydrophobicity

0.300

Chemical_Mass

632.7892

Monoisotopic_Mass

632.3885

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 27.07 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Lassoued I., Mora L., Barkia A., Aristoy M.-C., Nasri M., Toldra F.

Title

Angiotensin I-converting enzyme inhibitory peptides FQPSF and LKYPI identified in Bacillus subtilis A26 hydrolysate of thornback ray muscle. Int. J. Food Sci. Food Technol., 51, 1604-1609, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@]([H])(C(O)=O)[C@@]([H])(C)CC InChI=1S/C32H52N6O7/c1-5-20(4)27(32(44)45)37-30(42)26-10-8-16-38(26)31(43)25(18-21-11-13-22(39)14-12-21)36-29(41)24(9-6-7-15-33)35-28(40)23(34)17-19(2)3/h11-14,19-20,23-27,39H,5-10,15-18,33-34H2,1-4H3,(H,35,40)(H,36,41)(H,37,42)(H,44,45)/t20-,23-,24-,25-,26-,27-/m0/s1 InChIKey=FZWDRWMBYFWEJH-BCAOEVRMSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide identified in thornback ray muscle (Raja clavata) Bacillus subtilis A26 hydrolysate. IC50 value of synthetic peptide was 27.07 uM.

Number_of_Residues

5