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Peptide record

TPDB01074

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB01074
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
LKP
Physicochemical Analysis
C17H32N4O4
ARNDCEQGHIMFSTWYV
LKP
356.47
10.10
1
0
1
+1
0.88
-0.567
130.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C17H32N4O4
356.47
10.10
+1
0.88
-0.567
356.4591
356.2416
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.32 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Fujita H., Yokoyama K., Yoshikawa M.
Classification of antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J. Food Sci., 65, 564-569, 2000
2000
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C17H32N4O4/c1-11(2)10-12(19)15(22)20-13(6-3-4-8-18)16(23)21-9-5-7-14(21)17(24)25/h11-14H,3-10,18-19H2,1-2H3,(H,20,22)(H,24,25)/t12-,13-,14-/m0/s1 InChIKey: RTIRBWJPYJYTLO-IHRRRGAJSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide released from myosin by simulated gastric juice. Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S., 2010, Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436 Peptide obtained also from egg white protein hydrolysate. Huang W.-Y., Majumder K., Wu J., 2010, Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interactions with phytochemicals. Food Chem., 123, 635-641 Peptide reduced blood pressure in adult male SHRs. Majumder K., Chakrabarti S., Morton J.S., Panahi S., Kaufman S., Davidge S.T., Wu J., 2015, Egg-derived ACE-inhibitory peptides IQW and LKP reduce blood pressure in spontaneously hypertensive rats. Food Chem.,13, 50-60 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8216)
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.32 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Fujita H., Yokoyama K., Yoshikawa M.
Classification of antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J. Food Sci., 65, 564-569, 2000
2000
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C17H32N4O4/c1-11(2)10-12(19)15(22)20-13(6-3-4-8-18)16(23)21-9-5-7-14(21)17(24)25/h11-14H,3-10,18-19H2,1-2H3,(H,20,22)(H,24,25)/t12-,13-,14-/m0/s1 InChIKey: RTIRBWJPYJYTLO-IHRRRGAJSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide released from myosin by simulated gastric juice. Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S., 2010, Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436 Peptide obtained also from egg white protein hydrolysate. Huang W.-Y., Majumder K., Wu J., 2010, Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interactions with phytochemicals. Food Chem., 123, 635-641 Peptide reduced blood pressure in adult male SHRs. Majumder K., Chakrabarti S., Morton J.S., Panahi S., Kaufman S., Davidge S.T., Wu J., 2015, Egg-derived ACE-inhibitory peptides IQW and LKP reduce blood pressure in spontaneously hypertensive rats. Food Chem.,13, 50-60 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8216)
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
3