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Peptide record

TPDB01071

Peptide derived from ovine alpha S2-casein (165–170) ACE inhibitors Antibacterial Antihypertensive Antioxidant standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB01071
Peptide derived from ovine alpha S2-casein (165–170)
ACE inhibitors Antibacterial Antihypertensive Antioxidant
Anti-infective peptides Cardiometabolic peptides Functional / health-promoting peptides
FermFooDB Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antihypertensive, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
LKKISQ
Physicochemical Analysis
C32H61N9O9
ARNDCEGHMFPTWYV
K
715.89
10.60
2
0
2
+2
1.82
-0.633
130.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C32H61N9O9
715.89
10.60
+2
1.82
-0.633
715.8792
715.4578
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
2.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Lopez-Exposito I., Quiros A., Amigo L., Recio I.
Casein hydrolysates as a source of antimicrobial, antioxidant and antihypertensive peptides. Lait, 87 (2007), 241–249.
2007
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O)[C@@]([H])(C)CC InChI=1S/C32H61N9O9/c1-5-19(4)26(31(48)40-24(17-42)30(47)39-23(32(49)50)12-13-25(36)43)41-29(46)22(11-7-9-15-34)38-28(45)21(10-6-8-14-33)37-27(44)20(35)16-18(2)3/h18-24,26,42H,5-17,33-35H2,1-4H3,(H2,36,43)(H,37,44)(H,38,45)(H,39,47)(H,40,48)(H,41,46)(H,49,50)/t19-,20-,21-,22-,23-,24-,26-/m0/s1 InChIKey=BTDBLUHFSDYXHC-HXDUVXNTSA-N Peptide obtained by hydrolysis of ovine alpha S2-casein by use of porcine pepsin A. Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3961) the EROP-Moscow database the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
2.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Lopez-Exposito I., Quiros A., Amigo L., Recio I.
Casein hydrolysates as a source of antimicrobial, antioxidant and antihypertensive peptides. Lait, 87 (2007), 241–249.
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O)[C@@]([H])(C)CC InChI=1S/C32H61N9O9/c1-5-19(4)26(31(48)40-24(17-42)30(47)39-23(32(49)50)12-13-25(36)43)41-29(46)22(11-7-9-15-34)38-28(45)21(10-6-8-14-33)37-27(44)20(35)16-18(2)3/h18-24,26,42H,5-17,33-35H2,1-4H3,(H2,36,43)(H,37,44)(H,38,45)(H,39,47)(H,40,48)(H,41,46)(H,49,50)/t19-,20-,21-,22-,23-,24-,26-/m0/s1 InChIKey=BTDBLUHFSDYXHC-HXDUVXNTSA-N Peptide obtained by hydrolysis of ovine alpha S2-casein by use of porcine pepsin A. Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3961) the EROP-Moscow database the MBPDB database
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb FermFooDB
DFBP
Additional Detail Fields 1 fields
6