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Peptide record

TPDB01015

Antioxidative peptide P2 Antioxidant standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB01015
Antioxidative peptide P2
Antioxidant
Functional / health-promoting peptides
AnOxPePred - 1.0 AODB AoXpDb Multi-AOP pep-lab Peptipedia
standard
No
A 15-aa standard natural antioxidant peptide sequence curated from AnOxPePred - 1.0, AODB, AoXpDb, and other sources, with an available 3D structural model.
Sequence
LELHKLRSSHWFSRR
Physicochemical Analysis
C88H138N30O21
ANDCQGIMPTYV
RLS
1952.25
12.12
6
1
5
+3
3.09
-1.093
78.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
281.73
3
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
1
E
0
Q
0
G
2
H
0
I
3
L
1
K
0
M
1
F
0
P
3
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 2 I: 0 L: 3 K: 1 M: 0 F: 1 P: 0 S: 3 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
15
C88H138N30O21
1952.25
12.12
+3
3.09
-1.093
12.21
0.00
N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O
1952.23 Da
Evidence Records 1 records
Evidence 1 Activity

Activity

Antioxidative activity
The peptide P2 exhibited antioxidative activity in the thiobarbituric acid and was 61% higher than for α-tocopherol (data not shown). Lipid peroxidation in hepatocytes cultured overnight with the antioxidant peptide P2 was significantly lower than in hepatocytes cultured without P2 (2.6 ± 0.1 vs. 1.9 ± 0.1 μM malondialdehyde, mean ± standard error of the mean, P < 0.05).
Literature report: N.D Prediction: ToxinPred
Antioxidant

Assay & Model

lipid peroxidation
Enzymatic hydrolysis
Peptide obtained by hydrolysis of lecithin-free egg yolk protein by use of Alcalase for 18 h at 50 ℃

Source & Reference

AODB AoXpDb
Park, P.-J., Jung, W.-K., Nam, K.-S., Shahidi, F., Kim, S.-K. Purification and characterization of antioxidative peptides from protein hydrolysate of lecithin-free egg yolk. Journal of the American Oil Chemists' Society. 2001, 78, 651-6.
10.1007/s11746-001-0321-0
[1] Se-Kwon K, Hyun-Chel L, He-Guk B, et al. Isolation and Characterization of Antioxidative Peptides from Enzymatic Hydrolysates of Yellowfin Sole Skin Gelatin[J]. Korean Journal of Fisheries & Aquatic Sciences, 1996, 29(2).
2001
DFBP

Other

Native peptide
Animal
Egg
Lecithin-free egg yolk protein