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Peptide record

TPDB01014

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB01014
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
LEK
Physicochemical Analysis
C17H32N4O6
ARNDCQGHIMFPSTWYV
ELK
388.46
6.94
1
1
1
-0
2.45
-1.200
130.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C17H32N4O6
388.46
6.94
-0
2.45
-1.200
388.4579
388.2314
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
794.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C17H32N4O6/c1-10(2)9-11(19)15(24)20-12(6-7-14(22)23)16(25)21-13(17(26)27)5-3-4-8-18/h10-13H,3-9,18-19H2,1-2H3,(H,20,24)(H,21,25)(H,22,23)(H,26,27)/t11-,12-,13-/m0/s1 InChIKey: HQUXQAMSWFIRET-AVGNSLFASA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

EC50
Antihypertensive
794.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C17H32N4O6/c1-10(2)9-11(19)15(24)20-12(6-7-14(22)23)16(25)21-13(17(26)27)5-3-4-8-18/h10-13H,3-9,18-19H2,1-2H3,(H,20,24)(H,21,25)(H,22,23)(H,26,27)/t11-,12-,13-/m0/s1 InChIKey: HQUXQAMSWFIRET-AVGNSLFASA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

NA
DFBP
Additional Detail Fields 1 fields
3