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Peptide record

TPDB01000

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB01000
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AoXpDb
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
LDIQK
Physicochemical Analysis
C27H49N7O9
ARNCEGHMFPSTWYV
DQILK
615.73
6.75
1
1
2
-0
1.93
-0.520
156.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C27H49N7O9
615.73
6.75
-0
1.93
-0.520
615.7175
615.3580
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
17.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315, 2006
2006
book

Other

5
BIOPEP-UWM database of bioactive peptides N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C27H49N7O9/c1-5-15(4)22(34-25(40)19(13-21(36)37)33-23(38)16(29)12-14(2)3)26(41)31-17(9-10-20(30)35)24(39)32-18(27(42)43)8-6-7-11-28/h14-19,22H,5-13,28-29H2,1-4H3,(H2,30,35)(H,31,41)(H,32,39)(H,33,38)(H,34,40)(H,36,37)(H,42,43)/t15-,16-,17-,18-,19-,22-/m0/s1 InChIKey=YBSCDHHMDIRQTJ-LXYCOOOUSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
17.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315, 2006
2006
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C27H49N7O9/c1-5-15(4)22(34-25(40)19(13-21(36)37)33-23(38)16(29)12-14(2)3)26(41)31-17(9-10-20(30)35)24(39)32-18(27(42)43)8-6-7-11-28/h14-19,22H,5-13,28-29H2,1-4H3,(H2,30,35)(H,31,41)(H,32,39)(H,33,38)(H,34,40)(H,36,37)(H,42,43)/t15-,16-,17-,18-,19-,22-/m0/s1 InChIKey=YBSCDHHMDIRQTJ-LXYCOOOUSA-N
Additional Detail Fields 1 fields
5