TPDB

3D PDB MODEL

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TPDB ID TPDB00988

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

LAPSTIK

FASTA

>TPDB00988|ACE inhibitors;Antioxidant|length=7
LAPSTIK

Formula C33H60N8O10

Absent Amino Acids RNDCEQGHMFWYV

Common Amino Acids AILKPST

Mass 728.89

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index 0.67

Hydrophobicity 0.443

Aliphatic Index 125.71

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

1

L

1

K

0

M

0

F

1

P

1

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0

Length

7

Formula

C33H60N8O10

Mass

728.89

PI

10.10

Net Charge

+1

Boman Index

0.67

Hydrophobicity

0.443

Chemical_Mass

728.8747

Monoisotopic_Mass

728.4418

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 15.29 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zielińska E., Karaś M., Baraniak B., Jakubczyk A.

Title

Evaluation of ACE, alpha‑glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects. Eur. Food Res. Technol., 246, 1361-1369, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C33H60N8O10/c1-7-18(4)25(30(47)37-22(33(50)51)11-8-9-13-34)39-31(48)26(20(6)43)40-28(45)23(16-42)38-29(46)24-12-10-14-41(24)32(49)19(5)36-27(44)21(35)15-17(2)3/h17-26,42-43H,7-16,34-35H2,1-6H3,(H,36,44)(H,37,47)(H,38,46)(H,39,48)(H,40,45)(H,50,51)/t18-,19-,20+,21-,22-,23-,24-,25-,26-/m0/s1 InChIKey=RZGYKXWBKAWARZ-VOPNCDMXSA-N Inhibitor of pancreatic lipase according to the BIOPEP-UWM database of bioactive peptides (ID 9819) Inhibitor of Alpha-amylase (EC 3.2.1.1) to the BIOPEP-UWM database of bioactive peptides (ID 9820)

Number_of_Residues

7