TPDB

3D PDB MODEL

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TPDB ID TPDB00987

Peptide_Name

ACE inhibitor from egg yolk protein dipeptidyl peptidase IV inhibitor (DPP-IV inhibitor)

Activity

ACE inhibitors Antioxidant iDPPIV

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AnOxPePred - 1.0 AODB AoXpDb Multi-AOP iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (ACE inhibitors, Antioxidant, and iDPPIV) peptide sequence curated from Peptipedia, AnOxPePred - 1.0, AODB, and other sources, with an available 3D structural model.

Sequence

LAPSLPGKPKPD

FASTA

>TPDB00987|ACE inhibitors;Antioxidant;iDPPIV|length=12
LAPSLPGKPKPD

Formula C56H94N14O16

Absent Amino Acids RNCEQHIMFTWYV

Common Amino Acids P

Mass 1219.45

PI 9.88

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 3

Net Charge +1

Boman Index 3.86

Hydrophobicity -0.792

Aliphatic Index 73.33

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

0

N

1

D

0

C

0

E

0

Q

1

G

0

H

0

I

2

L

2

K

0

M

0

F

4

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 4 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

12

Formula

C56H94N14O16

Mass

1219.45

PI

9.88

Net Charge

+1

Boman Index

3.86

Hydrophobicity

-0.792

Chemical_Mass

1219.4260

Monoisotopic_Mass

1218.6950

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 1.97 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors

Eckert E., Zambrowicz A., Pokora M., Setner B., Dąbrowska A., Szołtysik M., Szewczuk Z., Polanowski A., Trziszka T., Chrzanowska J.

Title

Egg-yolk protein by-product as a source of ACE-inhibitory peptides obtained with using unconventional proteinase from Asian pumpkin (Cucurbita ficifolia). Journal of Proteomics 110, 107-116, 2014

Year 2014

Literature Source Journal

Other

Number of Residues 12

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)O InChI=1S/C56H94N14O16/c1-31(2)26-34(59)46(75)61-33(5)52(81)67-22-11-17-41(67)51(80)66-39(30-71)47(76)64-37(27-32(3)4)55(84)68-23-10-16-40(68)48(77)60-29-44(72)62-35(14-6-8-20-57)53(82)69-24-12-18-42(69)49(78)63-36(15-7-9-21-58)54(83)70-25-13-19-43(70)50(79)65-38(56(85)86)28-45(73)74/h31-43,71H,6-30,57-59H2,1-5H3,(H,60,77)(H,61,75)(H,62,72)(H,63,78)(H,64,76)(H,65,79)(H,66,80)(H,73,74)(H,85,86)/t33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1 InChIKey: GPHDNVHMTOABLZ-QMOUKIQXSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8547) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 8548) Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8550)

Evidence 2 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB AoXpDb

Source DFBP

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 361.50 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Zambrowicz A., Eckert E., Pokora M., Bobak Ł., Dąbrowska A., Szołtysik M., Trziszka T., Chrzanowska J.

Title

Antioxidant and antidiabetic activities of peptides isolated from a hydrolysate of an egg-yolk protein by-product prepared with a proteinase from Asian pumpkin (Cucurbita ficifolia). RSC Adv. 5, 10460-10467, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 12

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)O InChI=1S/C56H94N14O16/c1-31(2)26-34(59)46(75)61-33(5)52(81)67-22-11-17-41(67)51(80)66-39(30-71)47(76)64-37(27-32(3)4)55(84)68-23-10-16-40(68)48(77)60-29-44(72)62-35(14-6-8-20-57)53(82)69-24-12-18-42(69)49(78)63-36(15-7-9-21-58)54(83)70-25-13-19-43(70)50(79)65-38(56(85)86)28-45(73)74/h31-43,71H,6-30,57-59H2,1-5H3,(H,60,77)(H,61,75)(H,62,72)(H,63,78)(H,64,76)(H,65,79)(H,66,80)(H,73,74)(H,85,86)/t33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1 InChIKey: GPHDNVHMTOABLZ-QMOUKIQXSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 8388) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8547) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 8548)

Number_of_Residues

12