TPDB

3D PDB MODEL

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TPDB ID TPDB00982

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AnOxPePred - 1.0 AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AnOxPePred - 1.0, AODB, and other sources, with an available 3D structural model.

Sequence

LALPA

FASTA

>TPDB00982|ACE inhibitors;Antioxidant|length=5
LALPA

Formula C23H41N5O6

Absent Amino Acids RNDCEQGHIKMFSTWYV

Common Amino Acids AL

Mass 483.61

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 4

Net Charge -0

Boman Index -1.01

Hydrophobicity 1.920

Aliphatic Index 196.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

2

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

2

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C23H41N5O6

Mass

483.61

PI

6.02

Net Charge

-0

Boman Index

-1.01

Hydrophobicity

1.920

Chemical_Mass

483.5999

Monoisotopic_Mass

483.3047

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Girgih AT, He R, Malomo SA, Offengenden M, Wu J, Aluko RE.

Title

Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides. J. Funct. Foods 6, 384–394.

Year 2014

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)O InChI= 1S/C23H41N5O6/c1-12(2)10-16(24)20(30)25-14(5)19(29)27-17(11-13(3)4)22(32)28-9-7-8-18(28)21(31)26-15(6)23(33)34/h12-18H,7-11,24H2,1-6H3,(H,25,30)(H,26,31)(H,27,29)(H,33,34)/t14-,15-,16-,17-,18-/m0/s1 InChIKey: GFWBSWMJSHWGTC-ATIWLJMLSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9991) Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 9993)

Evidence 2 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB AoXpDb

Source DFBP

Number_of_Residues

5