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Peptide record

TPDB00964

ACE inhibitor from wakame dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Hypotensive peptide ACE inhibitors Antibacterial Antifungal Antihypertensive Antioxidant iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB00964
ACE inhibitor from wakame dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Hypotensive peptide
ACE inhibitors Antibacterial Antifungal Antihypertensive Antioxidant iDPPIV
Anti-infective peptides Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia CAFPdb dbAMP AHTPDB AHTpin AODB Multi-AOP iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
KY
Physicochemical Analysis
C15H23N3O4
ARNDCEQGHILMFPSTWV
KY
309.37
9.74
1
0
1
+1
0.05
-2.600
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
481.63
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
2
C15H23N3O4
309.37
9.74
+1
0.05
-2.600
309.3599
309.1683
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
7.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Suetsuna K., Maekawa K., Chen J.-R.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315.
2004
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C15H23N3O4/c16-8-2-1-3-12(17)14(20)18-13(15(21)22)9-10-4-6-11(19)7-5-10/h4-7,12-13,19H,1-3,8-9,16-17H2,(H,18,20)(H,21,22)/t12-,13-/m0/s1 InChIKey=MYTOTTSMVMWVJN-STQMWFEESA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8819) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10464) the DFBP database Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides, the DFBP database
Evidence 2 Activity

Activity

IC50
Antihypertensive
7.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Suetsuna K., Maekawa K., Chen J.-R.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315.
2004
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C15H23N3O4/c16-8-2-1-3-12(17)14(20)18-13(15(21)22)9-10-4-6-11(19)7-5-10/h4-7,12-13,19H,1-3,8-9,16-17H2,(H,18,20)(H,21,22)/t12-,13-/m0/s1 InChIKey=MYTOTTSMVMWVJN-STQMWFEESA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8819) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10464) the DFBP database Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides, the DFBP database
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Blood pressure lowering in vivo in rats
hypotensive
hyp

Source & Reference

AHTPDB
Suetsuna K., Maekawa K., Chen J.-R.
Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats. J. Nutr. Biochem., 15, 267-272, 2004
2024
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C15H23N3O4/c16-8-2-1-3-12(17)14(20)18-13(15(21)22)9-10-4-6-11(19)7-5-10/h4-7,12-13,19H,1-3,8-9,16-17H2,(H,18,20)(H,21,22)/t12-,13-/m0/s1 InChIKey=MYTOTTSMVMWVJN-STQMWFEESA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BindingDB database the BIOPEP-UWM database of bioactive peptides (ID 7691) the ChEMBL database the DFBP database, the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8819) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10464) the DFBP database
Evidence 4 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Evidence 5 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C15H23N3O4/c16-8-2-1-3-12(17)14(20)18-13(15(21)22)9-10-4-6-11(19)7-5-10/h4-7,12-13,19H,1-3,8-9,16-17H2,(H,18,20)(H,21,22)/t12-,13-/m0/s1 InChIKey=MYTOTTSMVMWVJN-STQMWFEESA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BindingDB database the BIOPEP-UWM database of bioactive peptides (ID 7691) the ChEMBL database the DFBP database, the EROP-Moscow database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10464) the DFBP database Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides, the DFBP database
Additional Detail Fields 1 fields
2