TPDB

3D PDB MODEL

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TPDB ID TPDB00959

Peptide_Name

ACE inhibitor from b-casein (169-175)

Activity

ACE inhibitors Antihypertensive Antioxidant Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides

Database_Source

FermFooDB pep-lab Peptipedia AHTPDB AHTpin Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.

Sequence

KVLPVPQ

FASTA

>TPDB00959|ACE inhibitors;Antihypertensive;Antioxidant;Neuropeptide|length=7
KVLPVPQ

Formula C37H65N9O9

Absent Amino Acids ARNDCEGHIMFSTWY

Common Amino Acids PV

Mass 779.98

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index 2.05

Hydrophobicity 0.229

Aliphatic Index 138.57

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

1

L

1

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

7

Formula

C37H65N9O9

Mass

779.98

PI

10.10

Net Charge

+1

Boman Index

2.05

Hydrophobicity

0.229

Chemical_Mass

779.9643

Monoisotopic_Mass

779.4890

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 1000.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source FermFooDB

Authors Maeno M., Yamamoto N., Takano T.

Title

Identification of antihypertensive peptides from casein hydrolysate produced by proteinase from Lactobacillus helveticus. J.Dairy Sci., 73, 1316-1321

Year 1996

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C37H65N9O9/c1-20(2)19-25(42-34(51)29(21(3)4)43-31(48)23(39)11-7-8-16-38)35(52)45-17-9-13-27(45)33(50)44-30(22(5)6)36(53)46-18-10-12-26(46)32(49)41-24(37(54)55)14-15-28(40)47/h20-27,29-30H,7-19,38-39H2,1-6H3,(H2,40,47)(H,41,49)(H,42,51)(H,43,48)(H,44,50)(H,54,55)/t23-,24-,25-,26-,27-,29-,30-/m0/s1 InChIKey=HJYMFKIKNPNGPA-YYLRFZLMSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 1000.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB FermFooDB

Authors Maeno M., Yamamoto N., Takano T.

Title

Identification of antihypertensive peptides from casein hydrolysate produced by proteinase from Lactobacillus helveticus. J.Dairy Sci., 73, 1316-1321

Year 1996

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C37H65N9O9/c1-20(2)19-25(42-34(51)29(21(3)4)43-31(48)23(39)11-7-8-16-38)35(52)45-17-9-13-27(45)33(50)44-30(22(5)6)36(53)46-18-10-12-26(46)32(49)41-24(37(54)55)14-15-28(40)47/h20-27,29-30H,7-19,38-39H2,1-6H3,(H2,40,47)(H,41,49)(H,42,51)(H,43,48)(H,44,50)(H,54,55)/t23-,24-,25-,26-,27-,29-,30-/m0/s1 InChIKey=HJYMFKIKNPNGPA-YYLRFZLMSA-N

Number_of_Residues

7