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Peptide record

TPDB00942

ACE inhibitor from anchovy and bonito dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antioxidant Bitter iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB00942
ACE inhibitor from anchovy and bonito dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antioxidant Bitter iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Food sensory peptides Functional / health-promoting peptides
Peptipedia CAFPdb dbAMP AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
KP
Physicochemical Analysis
C11H21N3O3
ARNDCEQGHILMFSTWYV
KP
243.31
10.10
1
0
0
+1
1.44
-2.750
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C11H21N3O3
243.31
10.10
+1
1.44
-2.750
243.3019
243.1578
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
22.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Ichimura T., Hu J., Aita D. Q., Maruyama S.
Angiotensin I-converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish sauce. J. Biosci. Bioeng., 96, 496-499, 2003
2003
Journal

Other

2
BIOPEP database of bioactive peptides SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N)C(=O)O InChI=1S/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/t8-,9-/m0/s1 InChIKey: AIXUQKMMBQJZCU-IUCAKERBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Antioxidative peptide according to BIOPEP database of bioactive peptides (ID 8218) Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to BIOPEP database of bioactive peptides (ID 8519) Bitter peptide according to BIOPEP database of sensory peptides and amino acids Peptide found in fish sauce. Ichimura T., Hu J., Aita D. Q., Maruyama S., 2003, Angiotensin I-converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish sauce. J. Biosci. Bioeng., 96, 496-499 Peptide found in chicken egg protein hydrolysate. Huang W.-Y., Majumder K., Wu J., 2010, Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interactions with phytochemicals. Food Chem., 123, 635-641
Evidence 2 Activity

Activity

IC50
Antihypertensive
22.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Ichimura T., Hu J., Aita D. Q., Maruyama S.
Angiotensin I-converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish sauce. J. Biosci. Bioeng., 96, 496-499, 2003
2003
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP database of bioactive peptides SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N)C(=O)O InChI=1S/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/t8-,9-/m0/s1 InChIKey: AIXUQKMMBQJZCU-IUCAKERBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Antioxidative peptide according to BIOPEP database of bioactive peptides (ID 8218) Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to BIOPEP database of bioactive peptides (ID 8519) Bitter peptide according to BIOPEP database of sensory peptides and amino acids Peptide found in fish sauce. Ichimura T., Hu J., Aita D. Q., Maruyama S., 2003, Angiotensin I-converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish sauce. J. Biosci. Bioeng., 96, 496-499 Peptide found in chicken egg protein hydrolysate. Huang W.-Y., Majumder K., Wu J., 2010, Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interactions with phytochemicals. Food Chem., 123, 635-641
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Evidence 4 Activity

Activity

IC50
iDPPIV
2540.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Hatanaka T., Inoue Y., Arima J., Kumagai Y., Usuki H., Kawakami K., Kimura M., Mukaihara T.
Production of dipeptidyl peptidase IV inhibitory peptides from defated rice bran. Food Chem., 134, 797-802
2012
Journal

Other

2
BIOPEP database bioactive peptides SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N)C(=O)O InChI=1S/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/t8-,9-/m0/s1 InChIKey: AIXUQKMMBQJZCU-IUCAKERBSA-N Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001) according to BIOPEP database of bioactive peptides (ID 7810), EROP-Moscow database and AHTPDB database Antioxidative peptide according to BIOPEP database of bioactive peptides (ID 8218) Bitter peptide according to BIOPEP database of sensory peptides and amino acids Peptide found in fish sauce. Ichimura T., Hu J., Aita D. Q., Maruyama S., 2003, Angiotensin I-converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish sauce. J. Biosci. Bioeng., 96, 496-499 Peptide found in chicken egg protein hydrolysate. Huang W.-Y., Majumder K., Wu J., 2010, Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interactions with phytochemicals. Food Chem., 123, 635-641
Additional Detail Fields 1 fields
2