TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB00892

Peptide_Name

ACE inhibitor

Activity

Antihypertensive Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

AHTPDB AHTpin Peptipedia FermFooDB

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (Antihypertensive and Antioxidant) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.

Sequence

KAVPYPQ

FASTA

>TPDB00892|Antihypertensive;Antioxidant|length=7
KAVPYPQ

Formula C38H59N9O10

Absent Amino Acids RNDCEGHILMFSTW

Common Amino Acids P

Mass 801.94

PI 9.74

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index 1.43

Hydrophobicity -0.843

Aliphatic Index 55.71

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 185.80

Polar Residues 2

number

1

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

1

K

0

M

0

F

2

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

7

Formula

C38H59N9O10

Mass

801.94

PI

9.74

Net Charge

+1

Boman Index

1.43

Hydrophobicity

-0.843

Chemical_Mass

801.9270

Monoisotopic_Mass

801.4371

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB FermFooDB

Authors Magouz O., Ibrahim M. A. A., Mehanna N., Gensberger-Reigl S., Dalabasmaz S., Pischetsrieder M.

Title

Identification of the heptapeptide PR7 and octapeptide SF8 with potent antioxidative and angiotensin converting enzyme inhibitory activity from the fermented dairy by-product “Buttermilk". Food Front., 6, 837–851, 2025

Year 2025

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C38H59N9O10/c1-21(2)31(45-32(50)22(3)42-33(51)25(40)8-4-5-17-39)37(55)47-19-7-10-29(47)35(53)44-27(20-23-11-13-24(48)14-12-23)36(54)46-18-6-9-28(46)34(52)43-26(38(56)57)15-16-30(41)49/h11-14,21-22,25-29,31,48H,4-10,15-20,39-40H2,1-3H3,(H2,41,49)(H,42,51)(H,43,52)(H,44,53)(H,45,50)(H,56,57)/t22-,25-,26-,27-,28-,29-,31-/m0/s1 InChIKey=SWQQGBJFUFDZFQ-KTTLVNKPSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides

Number_of_Residues

7