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Peptide record

TPDB00879

ACE inhibitor Hypotensive peptide ACE inhibitors Antihypertensive Antioxidant Neuropeptide standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB00879
ACE inhibitor Hypotensive peptide
ACE inhibitors Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
FermFooDB Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
IY
Physicochemical Analysis
C15H22N2O4
ARNDCEQGHLKMFPSTWV
IY
294.35
5.94
0
0
2
-0
-1.25
1.600
195.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1490
506.20
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
2
C15H22N2O4
294.35
5.94
-0
-1.25
1.600
294.3453
294.1574
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
2.10 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245, 1994
1994
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)[C@H](CC)C InChI=1S/C15H22N2O4/c1-3-9(2)13(16)14(19)17-12(15(20)21)8-10-4-6-11(18)7-5-10/h4-7,9,12-13,18H,3,8,16H2,1-2H3,(H,17,19)(H,20,21)/t9-,12-,13-/m0/s1 InChIKey: MUFXDFWAJSPHIQ-XDTLVQLUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 IC50(EC50) of peptide ranges from 2,1 to 3,7 uM. Loponen J., 2004, Angiotensin converting enzyme inhibitory peptides in Finnish cereals: a database survey. Agric. Food Sci., 13, 39-45 Peptide obtained from the following resources: soybean protein hydrolysate Beermann C., Euler M., Herzberg J., Stahl B., 2009, Anti-oxidative capacity of enzymatically released peptides from soybean protein isolate. Eur. Food Res. Technol., 229, 637–644 amaranth proteins: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 bovine collagen hydrolysate: Herregods G., Van Camp J., Morel N., Ghesquière B., Gevaert K., Vercruysse L., Dierckx S., Quanten E., Smagghe G., 2011, Angiotensin I-converting enzyme inhibitory activity of gelatin hydrolysates and identification of bioactive peptides. J. Agric. Food Chem., 59, 552-558 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 7873) the PlantPepDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
2.10 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245, 1994
1994
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)[C@H](CC)C InChI=1S/C15H22N2O4/c1-3-9(2)13(16)14(19)17-12(15(20)21)8-10-4-6-11(18)7-5-10/h4-7,9,12-13,18H,3,8,16H2,1-2H3,(H,17,19)(H,20,21)/t9-,12-,13-/m0/s1 InChIKey: MUFXDFWAJSPHIQ-XDTLVQLUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 IC50(EC50) of peptide ranges from 2,1 to 3,7 uM. Loponen J., 2004, Angiotensin converting enzyme inhibitory peptides in Finnish cereals: a database survey. Agric. Food Sci., 13, 39-45 Peptide obtained from the following resources: soybean protein hydrolysate Beermann C., Euler M., Herzberg J., Stahl B., 2009, Anti-oxidative capacity of enzymatically released peptides from soybean protein isolate. Eur. Food Res. Technol., 229, 637–644 amaranth proteins: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 bovine collagen hydrolysate: Herregods G., Van Camp J., Morel N., Ghesquière B., Gevaert K., Vercruysse L., Dierckx S., Quanten E., Smagghe G., 2011, Angiotensin I-converting enzyme inhibitory activity of gelatin hydrolysates and identification of bioactive peptides. J. Agric. Food Chem., 59, 552-558 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 7873) the PlantPepDB database
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Blood pressure lowering in vivo in rats
hypotensive
hyp

Source & Reference

AHTPDB FermFooDB
Suetsuna K., Maekawa K., Chen J.-R.
Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats. J. Nutr. Biochem., 15, 267-272, 2004
2024
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)[C@H](CC)C InChI=1S/C15H22N2O4/c1-3-9(2)13(16)14(19)17-12(15(20)21)8-10-4-6-11(18)7-5-10/h4-7,9,12-13,18H,3,8,16H2,1-2H3,(H,17,19)(H,20,21)/t9-,12-,13-/m0/s1 InChIKey: MUFXDFWAJSPHIQ-XDTLVQLUSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTOPDB database the BIOPEP-UWM database of bioactive peptides (ID 3383) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 7873) the PlantPepDB database
Evidence 4 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB FermFooDB
DFBP
Additional Detail Fields 1 fields
2