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Peptide record

TPDB00869

ACE inhibitor Hypotensive peptide ACE inhibitors Antihypertensive Antioxidant Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB00869
ACE inhibitor Hypotensive peptide
ACE inhibitors Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
IVF
Physicochemical Analysis
C20H31N3O4
ARNDCEQGHLKMPSTWY
IFV
377.48
6.02
0
0
3
-0
-1.37
3.833
226.67
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
3
C20H31N3O4
377.48
6.02
-0
-1.37
3.833
377.4766
377.2307
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
33.11 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Miguel M., Alvarez Y., Lopez-Fandino R., Alonso M. J., Salaices M.
Vasodilator effects of peptides derived from egg white proteins. Regulatory Peptides, 140, 131-135, 2007
2007
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C20H31N3O4/c1-5-13(4)16(21)18(24)23-17(12(2)3)19(25)22-15(20(26)27)11-14-9-7-6-8-10-14/h6-10,12-13,15-17H,5,11,21H2,1-4H3,(H,22,25)(H,23,24)(H,26,27)/t13-,15-,16-,17-/m0/s1 InChIKey=WIYDLTIBHZSPKY-HJWJTTGWSA-N Hypotensive peptide according to the DFBP database the EROP-Moscow database Antioxidative peptide according to the DFBP database
Evidence 2 Activity

Activity

IC50
Antihypertensive
33.11 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Miguel M., Alvarez Y., Lopez-Fandino R., Alonso M. J., Salaices M.
Vasodilator effects of peptides derived from egg white proteins. Regulatory Peptides, 140, 131-135, 2007
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C20H31N3O4/c1-5-13(4)16(21)18(24)23-17(12(2)3)19(25)22-15(20(26)27)11-14-9-7-6-8-10-14/h6-10,12-13,15-17H,5,11,21H2,1-4H3,(H,22,25)(H,23,24)(H,26,27)/t13-,15-,16-,17-/m0/s1 InChIKey=WIYDLTIBHZSPKY-HJWJTTGWSA-N Hypotensive peptide according to the DFBP database the EROP-Moscow database Antioxidative peptide according to the DFBP database
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Lowering blood pressure in rats
hypotensive
hyp

Source & Reference

AHTPDB
Miguel M., Alvarez Y., Lopez-Fandino R., Alonso M. J., Salaices M.
Vasodilator effects of peptides derived from egg white proteins. Regulatory Peptides, 140, 131-135, 2007
2007
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C20H31N3O4/c1-5-13(4)16(21)18(24)23-17(12(2)3)19(25)22-15(20(26)27)11-14-9-7-6-8-10-14/h6-10,12-13,15-17H,5,11,21H2,1-4H3,(H,22,25)(H,23,24)(H,26,27)/t13-,15-,16-,17-/m0/s1 InChIKey=WIYDLTIBHZSPKY-HJWJTTGWSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 8508), the DFBP database the EROP-Moscow database Antioxidative peptide according to the DFBP database
Evidence 4 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
3