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Peptide record

TPDB00848

beta-lactokinin dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) renin inhibitor ACE inhibitors Antihypertensive Antioxidant Neuropeptide iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB00848
beta-lactokinin dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) renin inhibitor
ACE inhibitors Antihypertensive Antioxidant Neuropeptide iDPPIV
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
Peptipedia AHTPDB AnOxPePred - 1.0 AODB Multi-AOP iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AnOxPePred - 1.0, and other sources, with an available 3D structural model.
Sequence
IR
Physicochemical Analysis
C12H25N5O3
ANDCEQGHLKMFPSTWYV
RI
287.36
11.05
1
0
1
+1
0.50
0.000
195.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C12H25N5O3
287.36
11.05
+1
0.50
0.000
287.3576
287.1952
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
695.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Mullally M. M., Meisel H., FitzGerald R. J.
Synthetic peptides corresponding to -lactalbumin and -lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261
1996
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C12H25N5O3/c1-3-7(2)9(13)10(18)17-8(11(19)20)5-4-6-16-12(14)15/h7-9H,3-6,13H2,1-2H3,(H,17,18)(H,19,20)(H4,14,15,16)/t7-,8-,9-/m0/s1 InChIKey=HYXQKVOADYPQEA-CIUDSAMLSA-N Another value of peptide EC50 = 2.25 um Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476 Isolated from pea protein hydrolysate. Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476 Isolated from hen ovotransferrin hydrolysate Huang W.-Y., Majumder K., Wu J., 2010, Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interactions with phytochemicals. Food Chem., 123, 635-641 Found in amaranth (Amarantus hypochondriacus) proteins: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8215) Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 8246) Inhibitor of calmodulin-dependent phosphodiesterase 1 (CaMPDE) (EC 3.1.4.17) according to the BIOPEP-UWM database of bioactive peptides (ID 8247) Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8806)
Evidence 2 Activity

Activity

IC50
Antihypertensive
695.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Mullally M. M., Meisel H., FitzGerald R. J.
Synthetic peptides corresponding to -lactalbumin and -lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C12H25N5O3/c1-3-7(2)9(13)10(18)17-8(11(19)20)5-4-6-16-12(14)15/h7-9H,3-6,13H2,1-2H3,(H,17,18)(H,19,20)(H4,14,15,16)/t7-,8-,9-/m0/s1 InChIKey=HYXQKVOADYPQEA-CIUDSAMLSA-N Another value of peptide EC50 = 2.25 um Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476 Isolated from pea protein hydrolysate. Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476 Isolated from hen ovotransferrin hydrolysate Huang W.-Y., Majumder K., Wu J., 2010, Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interactions with phytochemicals. Food Chem., 123, 635-641 Found in amaranth (Amarantus hypochondriacus) proteins: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8215) Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 8246) Inhibitor of calmodulin-dependent phosphodiesterase 1 (CaMPDE) (EC 3.1.4.17) according to the BIOPEP-UWM database of bioactive peptides (ID 8247) Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8806)
Evidence 3 Activity

Activity

EC50
Antihypertensive
9.20 µM
Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007)
renin inhibitor
ren

Source & Reference

AHTPDB
Li H., Aluko R. E.,
Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476, 2010
2010
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C12H25N5O3/c1-3-7(2)9(13)10(18)17-8(11(19)20)5-4-6-16-12(14)15/h7-9H,3-6,13H2,1-2H3,(H,17,18)(H,19,20)(H4,14,15,16)/t7-,8-,9-/m0/s1 InChIKey=HYXQKVOADYPQEA-CIUDSAMLSA-N Information concerning Renin is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: A01.007 Isolated from bovine beta-lactoglobulin hydrolysate FitzGerald R. J., Meisel H., 1999, Lactokinins: Whey protein-derived ACE inhibitory peptides. Nahrung 43, 165-167 Isolated from hen ovotransferrin hydrolysate Huang W.-Y., Majumder K., Wu J., 2010, Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interactions with phytochemicals. Food Chem., 123, 635-641 Found in amaranth proteins: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database BIOPEP-UWM database of bioactive peptides (ID 3258) the EROP-Moscow database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8215) Inhibitor of calmodulin-dependent phosphodiesterase 1 (CaMPDE) (EC 3.1.4.17) according to the BIOPEP-UWM database of bioactive peptides (ID 8247) Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8806)
Evidence 4 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Evidence 5 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C12H25N5O3/c1-3-7(2)9(13)10(18)17-8(11(19)20)5-4-6-16-12(14)15/h7-9H,3-6,13H2,1-2H3,(H,17,18)(H,19,20)(H4,14,15,16)/t7-,8-,9-/m0/s1 InChIKey=HYXQKVOADYPQEA-CIUDSAMLSA-N Isolated from bovine beta-lactoglobulin hydrolysate FitzGerald R. J., Meisel H., 1999, Lactokinins: Whey protein-derived ACE inhibitory peptides. Nahrung 43, 165-167 Isolated from hen ovotransferrin hydrolysate Huang W.-Y., Majumder K., Wu J., 2010, Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interactions with phytochemicals. Food Chem., 123, 635-641 Found in amaranth proteins: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database BIOPEP-UWM database of bioactive peptides (ID 3258) the EROP-Moscow database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8215) Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 8246) Inhibitor of calmodulin-dependent phosphodiesterase 1 (CaMPDE) (EC 3.1.4.17) according to the BIOPEP-UWM database of bioactive peptides (ID 8247)
Additional Detail Fields 1 fields
2